A handcrafted multi-branch nerve scaffold for in vivo peripheral nerve regeneration
نام عام مواد
[Thesis]
نام نخستين پديدآور
Ridwan Fayaz Hossain
نام ساير پديدآوران
Choi, Yoonsu P.
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
The University of Texas Rio Grande Valley
تاریخ نشرو بخش و غیره
2015
مشخصات ظاهری
نام خاص و کميت اثر
44
يادداشت کلی
متن يادداشت
Committee members: Huq, Hasina F.; Islam, Nazmul
یادداشتهای مربوط به نشر، بخش و غیره
متن يادداشت
Place of publication: United States, Ann Arbor; ISBN=978-1-339-51384-3
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
M.S.E.
نظم درجات
Electrical Engineering
کسي که مدرک را اعطا کرده
The University of Texas Rio Grande Valley
امتياز متن
2015
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Arm and leg peripheral nerve injuries contribute largely to functional disability. These injuries seldom affect a single-line nerve; rather the injury goes beyond and disrupts the nerve tissue across multiple nerve paths. Here we investigate handcrafted PDMS based multi-branch nerve guidance conduit, which addresses this crucial branching from the sciatic nerve to aid with the regeneration to their appropriate distal targets. The design concept of the developed multiple branch nerve scaffolds is not specific for the sciatic nerve but can be modified for general use of all peripheral nerves and additional applications. Microchannels are also fabricated into a device in order to guide axons to reach the distal ends, which in turn allow regenerating nerves to reach the target muscles. Experiments are performed on Lewis rats to demonstrate the effectiveness of this nerve conduit. Successful nerve regeneration was confirmed from histological analysis of the harvested nerves from all four branches.