Surface engineered biosensors for the early detection of cancer
نام عام مواد
[Thesis]
نام نخستين پديدآور
Muhymin Islam
نام ساير پديدآوران
Iqbal, Samir
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
The University of Texas at Arlington
تاریخ نشرو بخش و غیره
2015
مشخصات ظاهری
نام خاص و کميت اثر
187
يادداشت کلی
متن يادداشت
Committee members: Butler, Donald; Ghosh, Santaneel; Kim, Young-Tae; Magnusson, Robert
یادداشتهای مربوط به نشر، بخش و غیره
متن يادداشت
Place of publication: United States, Ann Arbor; ISBN=978-1-339-42914-4
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
Ph.D.
نظم درجات
Electrical Engineering
کسي که مدرک را اعطا کرده
The University of Texas at Arlington
امتياز متن
2015
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Cancer commences in the building block of human body which is cells and in most of the cases remains silent at early stage. Diseases are only expressed at molecular and cellular level at primary stages. Recognition of diseases at this micro and nano level might reduce the mortality rate of cancer significantly. This research work aimed to introduce novel electronic biosensors for for identification of cancer at cellular level. The dissertation study focuses on 1) Label-Free Isolation of Metastatic Tumor Cells Using Filter Based Microfluidic device; 2) Nanotextured Polymer Substrates for Enhanced Cancer Cell Isolation and Cell Growth; 3) Nanotextured Microfluidic Channel for Electrical Profiling and Detection of Tumor Cells from Blood; and 4) Single Biochip for the Detection of Tumor Cells by Electrical Profile and Surface Immobilized Aptamer. Standard silicon processing techniques were followed to fabricate all of the biosensors. Nantoextruing and surface functionalizon were also incorporated to elevate the efficiency of the devices.