عنوان

Asymmetric synthesis of natural products

شابک

1118347307

شابک

1118347315

شابک

1118347323

شابک

1118347331

شابک

9781118347300

شابک

9781118347317

شابک

9781118347324

شابک

9781118347331

شماره

b566653

عنوان اصلي

Asymmetric synthesis of natural products

نام عام مواد

[Book]

نام نخستين پديدآور

Ari M.P. Koskinen, Department of Chemistry, Aalto University, School of Chemical Technology, Espoo, Finland.

وضعيت ويراست

Second edition

محل نشرو پخش و غیره

Hoboken, New Jersey

نام ناشر، پخش کننده و غيره

Wiley

تاریخ نشرو بخش و غیره

2012

نام خاص و کميت اثر

(1 texte électronique) : fichiers HTML et PDF

متن يادداشت

In Wiley online library.Titre de l'écran-titre (visionné le 5 octobre 2012).

متن يادداشت

Preface to the First Edition ix Preface to the Second Edition xi List of Common Abbreviations xiii 1 Introduction 1 1.1 Some properties of natural products 4 1.2 Natural products as drugs 7 1.3 Structures of natural products 10 1.4 Asymmetric synthesis of natural products 15 1.5 Synthetic organic chemistry 17 References 20 2 Chirality, Topology, and Asymmetric Synthesis 23 2.1 The need for enantiopure compounds 34 2.2 Determination of enantiomeric purity 38 2.3 Chirality and thermodynamic principles of asymmetric induction 42 2.4 Methods for obtaining chiral compounds 44 References 52 3 Asymmetric Synthesis 55 3.1 Allylic strain 55 3.2 Reactions of the carbonyl group 59 3.2.1 Nucleophilic additions on the carbonyl carbon 59 3.2.2 Reactions at the -carbon (enolate chemistry) 81 3.2.3 Reactions at the -carbon of an enone 95 3.3 Reactions of olefins 99 3.3.1 Oxidation 99 References 108 4 Sugars 115 4.1 Monosaccharides 116 4.1.1 Aldoses and ketoses 116 4.1.2 Deoxy sugars 122 4.1.3 Amino sugars 122 4.1.4 Sugar alcohols 125 4.1.5 Acidic sugars 125 4.2 Polysaccharides 127 4.3 Glycoproteins and proteoglycans 131 4.4 Glycolipids 134 4.5 Sugar antibiotics 134 4.6 Cyclitols 138 References 142 5 Amino Acids, Peptides, and Proteins 145 5.1 Amino acids 145 5.2 Peptides and proteins 149 5.3 Enzymes and receptors 153 5.4 Chemical modifications of peptides 154 5.5 Biosynthesis of amino acids 156 5.6 Asymmetric synthesis of amino acids 160 5.6.1 -Alkylation 162 5.6.2 Amination of ester enolates 167 5.6.3 Catalytic hydrogenation 169 5.6.4 Miscellaneous 170 5.6.5 Pepstatins 171 References 173 6 Nucleosides, Nucleotides, and Nucleic Acids 175 References 184 7 Polyketides 187 7.1 Biosynthesis 188 7.2 Fatty acids 190 7.2.1 Prostaglandins, thromboxanes, and leukotrienes 191 7.2.2 Sphingolipids 196 7.3 Polypropionates 200 7.3.1 Polyether antibiotics 200 7.3.2 Macrolides 201 7.3.3 Spiroketals 209 7.4 Aromatic polyketides 213 References 215 8 Terpenes 219 8.1 Terpenes 221 8.1.1 Monoterpenes 221 8.1.2 Sesquiterpenes 223 8.1.3 Diterpenes 228 8.1.4 Higher terpenes 230 8.2 Carotenoids 234 8.3 Steroids 235 8.3.1 Biosynthesis of steroids 240 8.3.2 Asymmetric synthesis of steroids 242 References 244 9 Shikimic Acid Derivatives 247 9.1 Case synthesis: Oseltamivir 251 References 254 10 Alkaloids 257 10.1 Heterocyclic alkaloids 258 10.1.1 Indole alkaloids 259 10.1.2 Pyrrolidine and tropane alkaloids 270 10.1.3 Quinoline and isoquinoline alkaloids 273 10.1.4 Izidine alkaloids 279 10.2 Alkaloids with exocyclic nitrogen 282 10.3 Polyamine alkaloids 283 10.4 Peptide alkaloids 283 10.5 Terpene alkaloids 284 References 285 Index 289

عنوان اصلي به زبان ديگر

Wiley online library.

موضوع مستند نشده

Asymétrie (Chimie)

موضوع مستند نشده

Produits naturels -- Synthèse.

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

Ari M.P. Koskinen, Department of Chemistry, Aalto University, School of Chemical Technology, Espoo, Finland.

مستند نام اشخاص تاييد نشده

Ari Koskinen

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y