عنوان

Toxicity assessment alternatives :

شابک

147576863X

شابک

1592597181

شابک

9781475768633

شابک

9781592597185

شماره

b547925

عنوان اصلي

Toxicity assessment alternatives :

نام عام مواد

[Book]

ساير اطلاعات عنواني

methods, issues, opportunities

نام نخستين پديدآور

edited by Harry Salem and Sidney A. Katz.

محل نشرو پخش و غیره

Totowa, N.J.

نام ناشر، پخش کننده و غيره

Humana Press

تاریخ نشرو بخش و غیره

©1999.

نام خاص و کميت اثر

(xiii, 262 pages) : illustrations

متن يادداشت

I. Recent Developments on Alternatives --;1 Tissue Engineering: An Important Technology for Assessment of Toxicity --;2 Tissue Engineering: Technology Applications and FDA Initiatives --;3 Electrical Resistance Method for Measuring Volume Changes in Astrocytes --;4 Cytotoxicity Profiles for a Series of Investigational Compounds Using Liver Slice Technology and Human-Derived Cell Cultures --;5 Antagonistic Interaction of Sodium Arsenite and Lead Sulfate with UV Light on Sister Chromatid Exchanges in Human Peripheral Lymphocytes --;6 The Role of Upper Airway Heat and Water Vapor Exchange in Hygroscopic Aerosol Deposition in the Human Airway: A Deposition Model --;7 Moving Average Interpolation for Malathion LC50 Estimation on Dugesia tigrina: Comparison with Probit and "One-Point" Methods --;8 Physiological Modeling of Benzo(a)pyrene Pharmacokinetics in the Rat --;II. Current Trends and Future Directions --;9 Resources for Biomedical Research: Opportunities for Alternatives --;III. Mechanistically Based Test Methods as Alternatives --;10 Endocrine Disruption in Wildlife: Scientific Processes and Principles for Evaluating Effects --;11 Mechanistic Animal-Replacement Approaches for Predicting Pharmacokinetics of Organic Chemicals --;IV. Use of Alternatives in Hazard Assessment Initiatives --;12 Validation of the CytosensorTM Microphysiometer for In Vitro Cytotoxicity Testing --;13 Sulfur Mustard Effects on Cell Yield Alter Viability Assessment in Normal Human Epidermal Keratinocytes --;14 Development of Human Keratinocyte Colonies for Confocal Microscopy and for Study of Calcium Effects on Growth Differentiation and Sulfur Mustard Lesions: A Model --;15 Phosgene-Induced Calcium Changes in Pulmonary Artery Endothelial Cells --;16 Enhanced Proteolytic Activity and Fc Receptor Expression in Human Epithelial Cells Following Exposure to Sulfur Mustard --;17 Altered Expression of lntracellular and Surface Antigens by Cultured Human Epidermal Keratinocytes Exposed to Sulfur Mustard --;18 Effect of Sulfur Mustard Exposure on Human Epidermal Keratinocyte Viability and Protein Content --;19 The Use of In Vitro Systems to Define Therapeutic Approaches to Cutaneous Injury by Sulfur Mustard --;20 Effects of Poly (ADP-Ribose) Polymerase Inhibitors on the Sulfur Mustard-Induced Disruption of the Higher-Order Nuclear Structure of Human Lymphocytes --;21 DNA Repair Enzymatic Response in Cultured Human Epidermal Keratinocytes Following Sulfur Mustard Exposure --;22 Human Hepatocytes: A Novel Animal Alternative --;V. Validation, Regulatory Acceptance, and Animal Protection Perspectives --;23 An Animal Protection Perspective --;24 Federal Interagency Activities Toward Validation and Regulatory Acceptance of Alternative Tests.

متن يادداشت

This text provides information from scientific and regulatory communities on achieved and accepted alternatives to animal testing, such as the use of transgenic models, the use of tissue cultures for the assessment of endocrine-disrupting chemicals, and the application of molecular modeling.

موضوع مستند نشده

Animal Testing Alternatives.

موضوع مستند نشده

Toxicity testing -- In vitro -- Methodology.

موضوع مستند نشده

Toxicity testing -- In vivo -- Methodology.

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

edited by Harry Salem and Sidney A. Katz.

مستند نام اشخاص تاييد نشده

Harry Salem

مستند نام اشخاص تاييد نشده

Sidney A Katz

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y