عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شابک
شابک
3642784518
شابک
9783642784514
شماره کتابشناسی ملی
شماره
b542199
عنوان و نام پديدآور
عنوان اصلي
Anxiolytic [beta]-Carbolines :
نام عام مواد
[Book]
ساير اطلاعات عنواني
From Molecular Biology to the Clinic
نام نخستين پديدآور
edited by David N. Stephens.
وضعیت نشر و پخش و غیره
محل نشرو پخش و غیره
Berlin, Heidelberg
نام ناشر، پخش کننده و غيره
Springer Berlin Heidelberg
تاریخ نشرو بخش و غیره
1993
مشخصات ظاهری
نام خاص و کميت اثر
(xi, 151 pages 62 illustrations, 9 illustrations in color.)
فروست
عنوان فروست
Psychopharmacology series, 11.
یادداشتهای مربوط به مندرجات
متن يادداشت
Discovery of?-Carboline Ligands for Benzodiazepine Receptors --?-Carboline-3-Carboxylic Acid Ethyl Ester: A Lead for New Psychotropic Drugs --;Molecular Biology of Gamma-Aminobutyric Acid Type A/Benzodiazepine Receptors --;Immunohistochemical Mapping of Gamma-Aminobutyric Acid Type A Receptor Alpha Subunits in Rat Central Nervous System --;Abecarnil is a Full Agonist at Some and a Partial Agonist at Other Recombinant Gamma-Aminobutyric Acid Type A Receptor Subtypes --;Pharmacological Evidence for Full Agonist Activity of Abecarnil at Certain Receptors --;Abecarnil: A Novel Anxiolytic with Mixed Full Agonist/Partial Agonist Properties in Animal Models of Anxiety and Sedation --;Abecarnil Shows Reduced Tolerance Development and Dependence Potential in Comparison to Diazepam --;Behavioral Pharmacology of Abecarnil in Baboons: Reduced Dependence and Abuse Potential --;Abecarnil Used to Treat Benzodiazepine Withdrawal --;Abecarnil, A New?-Carboline Anxiolytic: Preliminary Clinical Pharmacology.
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Since the discovery some 15 years ago of benzodiazepine modulatory sites associated with GABA A receptors, great effort has gone into understanding their molecular pharmacology and into developing new anxiolytic drugs that interact selectively with them. Prominent in this research has beenthe discovery that ~-carbolines, a different chemical class from benzodiazepines, also act at these receptors but that their effects are sometimes quite different from those of the benzodiazepines. This book documents the latest discoveries in the molecular biology of the GABA A receptor and reveals how an integration of the results of research inmolecular biology, synthetic chemistry, biochemical and behavioral pharmacology, and clinical pharmacology has paved the way forthe development of ~-carbolines from substances inducing anxiety and convulsions to a novel therapy for anxiety states, achieving a behavioral selectivity through selective actions at subtypes of receptors.
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Medicine.
موضوع مستند نشده
Psychiatry.
موضوع مستند نشده
Toxicology.
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
edited by David N. Stephens.
نام شخص - (مسئولیت معنوی برابر )
مستند نام اشخاص تاييد نشده
David N Stephens
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب اطلاعات رکورد کتابشناسی
نوع ماده
[Book]
اطلاعات دسترسی رکورد
تكميل شده
Y
