عنوان

Bioinformatics of non small cell lung cancer and the ras proto-oncogene

شابک

9789814585071

شابک

9789814585088

شابک

9814585076

شابک

9814585084

شماره

b538881

عنوان اصلي

Bioinformatics of non small cell lung cancer and the ras proto-oncogene

نام عام مواد

[Book]

نام نخستين پديدآور

Amita Kashyap, D. Bujamma, Naresh Babu M.

محل نشرو پخش و غیره

Heidelberg

نام ناشر، پخش کننده و غيره

Springer-Verlag

تاریخ نشرو بخش و غیره

[2015] 2015

نام خاص و کميت اثر

(1 recurs electrònic (vii, 72 pàgines)) : il·lustracions (algunes color)

عنوان فروست

SpringerBriefs in applied sciences and technology., Forensic and medical bioinformatics.

متن يادداشت

Descripció del recurs: el 2 de març de 2016.

متن يادداشت

Conté: Introduction --;Review of Literature --;Materials and Methods (Tools and Databases) --;Flowchart --;Conclusion.-References

متن يادداشت

Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10-30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.

موضوع مستند نشده

Bioinformàtica.

موضوع مستند نشده

Oncogens Ras.

موضوع مستند نشده

Pulmons -- Càncer.

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

Amita Kashyap, D. Bujamma, Naresh Babu M.

مستند نام اشخاص تاييد نشده

Amita Kashyap

مستند نام اشخاص تاييد نشده

D Bujamma

مستند نام اشخاص تاييد نشده

Naresh Babu M

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y