عنوان

Technical aspects of toxicological immunohistochemistry :

شابک

1493915169

شابک

9781493915163

شابک اشتباه

1493915150

شابک اشتباه

9781493915156

شماره

dltt

عنوان اصلي

Technical aspects of toxicological immunohistochemistry :

نام عام مواد

[Book]

ساير اطلاعات عنواني

system specified biomarkers /

نام نخستين پديدآور

Syed A. Aziz, Rekha Mehta, editors

نام خاص و کميت اثر

1 online resource

متن يادداشت

Includes index

متن يادداشت

Preface; Contents; Chapter 1: Immunohistochemistry: Overview, Its Potential, and Challenges; Overview; The Potential of IHC; Challenges; Conclusion; References; Chapter 2: Tissue Microarray Technology and Its Potential Applications in Toxicology and Toxicological Immunohistochemistry; Introduction; The Emergence and Dominance of Post-genomic Technologies; The Proliferation of Microarray Technologies; Tissue Microarrays; What Are TMAs?; Why Use TMAs?; How Is TMAs Produced?; TMA Resources; CHTN TMAs; The Tissue Array Research Program; National Disease Research Interchange

متن يادداشت

Application in IHC Perspectives; References; Chapter 5: Immunohistochemistry in the Study of Cancer Biomarkers for Oncology Drug Development; Introduction; Technical Aspects of IHC; Basic Procedure of IHC; Fixation; FFPE Tissue Section and Frozen Fresh Tissue Cryosection; Tissue Pretreatment and Antigen Retrieval; Blocking Considerations; Primary Antibody and Controls; Detection Systems; Direct Methods; Indirect Method; Combination of Detection Systems for Multiple Target Protein Detection; Chromagens; Counterstaining; Coverslip; IHC for Cancer Biomarker Studies

متن يادداشت

Cancer Biomarker Studies on Tissue Section Slides Cancer Biomarker Study on Cytological Preparation Slides; Assay Development; General Assay Development and Validation; Assay Development of Multi-fluorophore Labeling Techniques; Tumor Vascular Measurement; Circulating Tumor Cell Assessment; IHC Score; Score for Tumor Vasculature; Quantification of Microvessels and Target Receptors; Quantification of Hypoxic Protein Expression; Quantification of Pericyte Coverage; Score for Circulating Tumor Cells; Statistical Analysis; Companion Diagnostics; Sources of IHC Errors and Troubleshooting

متن يادداشت

Commercially Produced TMAs Bioinformatic Approaches for TMA Data Analysis; TMAs for Toxicological Research: Opportunities and Challenges; Applications in Toxicology; Conclusions; References; Chapter 3: Importance of Fluorescent In Situ Hybridization in Rodent Tumors; Introduction; Fluorescent In Situ Hybridization: A Conceptual Approach; DNA Probes; Single-Copy Probes; Whole-Genome Analysis in a Single Experiment with FISH-Based Technologies; Multiplex-FISH and Spectral Karyotyping Analysis; Comparative Genomic Hybridization Analyses; Microarrays Based Cytogenetics

متن يادداشت

Multicolor Banding Analysis of Centromeres and Telomeres in Tumors; Combining Approaches: An Improvement in Cytogenetic Characterization; RNA Analysis in Single Cells; Concluding Remarks; References; Chapter 4: Quantitation of Immunohistochemistry by Image Analysis Technique; Introduction; Tissue Microarrays; Tissue-Based Diagnosis and Types of Diagnoses; Basics of Image Analysis; Principles of Microscopic Image Analysis; Colour Space; Image Quality; Object Segmentation; Syntactic Structure Algorithms; Image Information and Feature Extraction; Region of Interest

بدون عنوان

0

بدون عنوان

8

بدون عنوان

8

بدون عنوان

8

بدون عنوان

8

متن يادداشت

This volume examines immunohistochemical methods for investigating the toxicologic pathology of rodent and otheranimal tissues.Eleven comprehensive chapters provide pathologists and researchers in various sub-disciplines of toxicology with an authoritative review of the methods ofimmunohistochemical staining in various target tissues. Further, this book explores the tissue-, antigen-, and antibody-specific problems that may be encountered during the staining procedures and provides potential avenues for resolving various methodological issues. Special attention is paid to the latest enhancement procedures for antigen retrieval and visualization as well as to image analysis and antigen quantification. Written by leading researchers in toxicology and pathology, this book is a significant resource for toxicologists and pathologists working with rodents and other animal models. The information in Technical Aspects of Toxicological Immunohistochemistry is rounded out bythe companion book,Toxicological Immunohistochemistrywhich examines mechanistic and predictive biomarkers for toxicological evaluation.

شماره استاندارد بين المللي کتاب و موسيقي

1493915150

موضوع مستند نشده

Immunohistochemistry.

موضوع مستند نشده

Immunotoxicology.

موضوع مستند نشده

RB

شماره

ويراست

شماره رده

مستند نام اشخاص تاييد نشده

Aziz, Syed A.

مستند نام اشخاص تاييد نشده

Mehta, Rekha

مستند نام تنالگان تاييد نشده

Ohio Library and Information Network.

تاريخ عمليات

20201222040504.1

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

کد کاربرگه

270410

تكميل شده

Y