عنوان

Advances in statistical bioinformatics :

شابک

1107027527 (hardback)

شابک

9781107027527 (hardback)

شماره

dltt

عنوان اصلي

Advances in statistical bioinformatics :

نام عام مواد

[Book]

ساير اطلاعات عنواني

models and integrative inference for high-throughput data /

نام نخستين پديدآور

edited by Kim-Anh Do, The University of Texas M.D. Anderson Cancer Center, Zhaohui Steven Qin, Emory University, Atlanta, GA, Marina Vannucci, Rice University, Houston, TX

نام خاص و کميت اثر

xv, 481 pages, 16 unnumbered pages of plates :

ساير جزييات

illustrations (some color) ;

ابعاد

24 cm

متن يادداشت

Includes bibliographical references and index

متن يادداشت

"When Sanger and Coulson first described a reliable, efficient method for DNA sequencing in 1975 (Sanger and Coulson, 1975), they made possible the full sequencing of both genes and entire genomes. Although the method was resource-intensive, many institutions invested in the necessary equipment, and Sanger sequencing remained the standard for the next 30 years. Refinement of the process increased read lengths from around 25 to 2 Mohlere, Wang, and Manyam almost 750 base pairs (Schadt et al., 2010, fig. 1). While this greatly increased efficiency and reliability, the Sanger method still required not only large equipment but significant human investment, as the process requires the work of several people. This prompted researchers and companies such as Applied Biosystems to seek improved sequencing techniques and instruments. Starting in the late 2000s, new instruments came on the market that, although they actually decreased read length, lessened run time and could be operated more easily with fewer human resources (Schadt et al., 2010). Despite discoveries that have illuminated new therapeutic targets, clarified the role of specific mutations in clinical response, and yielded new methods for diagnosis and predicting prognosis (Chin et al., 2011), the initial promise of genomic data has largely remained so far unfulfilled. The difficulties are numerous"--

موضوع مستند نشده

Bioinformatics-- Statistical methods

موضوع مستند نشده

Biometry

موضوع مستند نشده

Genetics-- Technique

شماره

ويراست

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

Do, Kim-Anh,1960-

مستند نام اشخاص تاييد نشده

Qin, Steven,1972-

مستند نام اشخاص تاييد نشده

Vannucci, Marina,1966-

تاريخ عمليات

20141128225518.0

قواعد فهرست نويسي ( بخش توصيفي )

rda

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y