عنوان

Statistics and data analysis for microarrays using R and Bioconductor /

شابک

1439809755 (hardback)

شابک

9781439809754 (hardback)

شماره

dltt

عنوان اصلي

Statistics and data analysis for microarrays using R and Bioconductor /

نام عام مواد

[Book]

نام نخستين پديدآور

Sorin Draghici

وضعيت ويراست

2nd ed

محل نشرو پخش و غیره

Boca Raton, FL :

نام ناشر، پخش کننده و غيره

CRC Press,

تاریخ نشرو بخش و غیره

c2012

نام خاص و کميت اثر

xlviii, 1042 p. :

ساير جزييات

ill. (chiefly col.) ;

ابعاد

25 cm. +

مواد همراه اثر

CD-ROM (4 3/4 in.)

عنوان فروست

Chapman & Hall/CRC mathematical and computational biology

متن يادداشت

Includes bibliographical references and index

متن يادداشت

"Preface Although the industry once suffered from a lack of qualified targets and candidate drugs, lead scientists must now decide where to start amidst the overload of biological data. In our opinion, this phenomenon has shifted the bottleneck in drug discovery from data collection to data anal- ysis, interpretation and integration. Life Science Informatics, UBS Warburg Market Report, 2001 One of the most promising tools available today to researchers in life sciences is the microarray technology. Typically, one DNA array will provide hundreds or thousands of gene expression values. However, the immense potential of this technology can only be realized if many such experiments are done. In order to understand the biological phenomena, expression levels need to be compared between species or between healthy and ill individuals or at different time points for the same individual or population of individuals. This approach is currently generating an immense quantity of data. Buried under this humongous pile of numbers lays invaluable biological information. The keys to understanding phenomena from fetal development to cancer may be found in these numbers. Clearly, powerful analysis techniques and algorithms are essential tools in mining these data. However, the computer scientist or statistician that does have the expertise to use advanced analysis techniques usually lacks the biological knowledge necessary to understand even the simplest biological phenomena. At the same time, the scientist having the right background to formulate and test biological hypotheses may feel a little uncomfortable when it comes to analyzing the data thus generated"--Provided by publisher

متن يادداشت

"Richly illustrated in color, Statistics and Data Analysis for Microarrays Using R and Bioconductor, Second Edition provides a clear and rigorous description of powerful analysis techniques and algorithms for mining and interpreting biological information. Omitting tedious details, heavy formalisms, and cryptic notations, the text takes a hands-on, example-based approach that teaches students the basics of R and microarray technology as well as how to choose and apply the proper data analysis tool to specific problems.New to the Second EditionCompletely updated and double the size of its predecessor, this timely second edition replaces the commercial software with the open source R and Bioconductor environments. Fourteen new chapters cover such topics as the basic mechanisms of the cell, reliability and reproducibility issues in DNA microarrays, basic statistics and linear models in R, experiment design, multiple comparisons, quality control, data pre-processing and normalization, Gene Ontology analysis, pathway analysis, and machine learning techniques. Methods are illustrated with toy examples and real data and the R code for all routines is available on an accompanying CD-ROM.With all the necessary prerequisites included, this best-selling book guides students from very basic notions to advanced analysis techniques in R and Bioconductor. The first half of the text presents an overview of microarrays and the statistical elements that form the building blocks of any data analysis. The second half introduces the techniques most commonly used in the analysis of microarray data"--Provided by publisher

موضوع مستند نشده

Bioconductor (Computer file)

موضوع مستند نشده

DNA microarrays-- Statistical methods

موضوع مستند نشده

Mathematical statistics-- Data processing

موضوع مستند نشده

R (Computer program language)

شماره

ويراست

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

Drăghici, Sorin

تاريخ عمليات

20120216020728.0

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y