عنوان

Apoptosis, senescence and cancer /

شابک

1588295273 (hbk.)

شابک

9781588295279 (hbk.)

شماره

b431763

عنوان اصلي

Apoptosis, senescence and cancer /

نام عام مواد

[Book]

نام نخستين پديدآور

edited by David A. Gewirtz, Shawn E. Holt, Steven Grant

وضعيت ويراست

2nd ed

محل نشرو پخش و غیره

Totowa, N.J. :

نام ناشر، پخش کننده و غيره

Humana Press,

تاریخ نشرو بخش و غیره

2007

نام خاص و کميت اثر

xvii, 599 p. :

ساير جزييات

ill. ;

ابعاد

26 cm

عنوان فروست

Cancer drug discovery and development

متن يادداشت

Includes bibliographical references and index

متن يادداشت

The intrinsic pathway of apoptosis. -- The extrinsic pathway of apoptosis. -- Evaluating the importance of apoptosis and other determinants of cell death and survival. -- Mitotic catastrophe. -- Autophagy and autophagic cell death. -- Regulation and function of detachment-induced cell death (anoikis) in cancer progression and metastasis. -- Structure and function of the telomere. -- Overview of senescence. -- Contributions of telomerase to tumorigenesis. -- The role of telomeres in genomic instability. -- Overview of the DNA damage checkpoint: ATM and ATR. -- Interactions between myc- and cyclin-dependent kinase inhibitors in cancer. -- Interplay between [gamma]H2AX and 53BP1 pathways in DNA double-strand break repair response. -- DNA-dependent protein kinase in repair, apoptosis, telomere maintenance, and chemotherapy. -- Resistance/signaling pathways. -- Ceramide and multidrug resistance. -- Chemo- and radiosensitization through inhibition of PI3K/Akt signaling. -- The advancement of epidermal growth factor receptor inhibitors in cancer therapy. -- Antimetabolites. -- Topoisomerase I poisons and apoptotic topoisomerase I-DNA complexes. -- Perturbations of cellular functions by topoisomerase II inhibitors: all roads lead to cell death? -- The significance of poly-targeting in apoptosis induction by alkylating agents and platinum drugs. -- Contributions of apoptosis and senescence to cytotoxicity produced by microtubule-stabilizing agents. -- Tyrosine kinase inhibitors. -- Monoclonal antibodies in lymphomas. -- Role of apoptosis in anti-angiogenic cancer therapies. -- Photodynamic therapy-induced apoptosis. -- Modulation of TRAIL signaling for cancer therapy

بدون عنوان

0

موضوع مستند نشده

Apoptosis

موضوع مستند نشده

Cancer cells-- Growth-- Regulation

موضوع مستند نشده

Cancer-- Chemotherapy

موضوع مستند نشده

Cancer-- Radiotherapy

موضوع مستند نشده

Apoptosis

موضوع مستند نشده

Cell Aging

موضوع مستند نشده

Neoplasms-- drug therapy

موضوع مستند نشده

Neoplasms-- radiotherapy

مستند نام اشخاص تاييد نشده

Gewirtz, David A

مستند نام اشخاص تاييد نشده

Grant, Steven

مستند نام اشخاص تاييد نشده

Holt, Shawn E

تاريخ عمليات

20080305104822.0

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y