عنوان

HPLC methods for clinical pharmaceutical analysis :a user's guide

شماره استاندارد

24856

نام نخستين پديدآور

Mascher, Hermann.

عنوان اصلي

HPLC methods for clinical pharmaceutical analysis :a user's guide

محل نشرو پخش و غیره

Weinheim

نام ناشر، پخش کننده و غيره

Wiley-VCH

تاریخ نشرو بخش و غیره

2012

نام خاص و کميت اثر

ix, 247 p. : ill. ; 25 cm.

متن يادداشت

Includes bibliographical references and index

متن يادداشت

1st ed

متن يادداشت

1.Introduction -- 1.1.First Question: Determination of Ibuprofen in Plasma -- 1.2.Second Question: Determination of Tryptophan in Urine -- 1.3.Third Question: Determination of Paclitaxel in Tissue -- 2.Planning of Analyses -- 2.1.Introduction -- 2.2.Limit of Detection )LOD( and Determination )LLOQ( -- 2.3.Detectors -- 2.4.Structure of the Analyte -- 2.5.Solubility of an Analyte -- 2.6.Selection of the Detector -- 3.Sample Preparation -- 3.1.Dilution -- 3.2.Protein Precipitation, Overview -- 3.3.Extraction -- 4.HPLC Separation -- 4.1.HPLC Pumps -- 4.2.Degasser -- 4.3.Injector -- 4.4.HPLC Columns -- 5.Detection -- 5.1.Detection in the Pharmaceutical/Bioanalytical Area -- 5.2.Detection in the "Clinical Area" )Therapy Control/Compliance( -- 6.Chemical Derivatization for Detection Enhancement -- 7.Validation Concepts -- 7.1.Introduction -- 7.2.Realization of the FDA Guideline -- 8.Practical Hints Concerning Stability, Destruction and Degradation Products -- 9.Metabolites -- 01.Internal Standards -- 11.Case Studies with Intensive Discussion for Each Substance -- 11.1.Acetylcarnitine in Plasma -- 11.2.Acetylcysteine in Plasma -- 11.3.Acyclovir in Plasma and Urine -- 11.4.Caffeine in Plasma -- 11.5.Diazepam in Plasma -- 11.6.Diclofenac in Plasma -- 11.7.Dihydralazine in Plasma -- 11.8.Duramycin )Moli1091( in Plasma -- 11.9.Fluticasone Propionate in Plasma -- 11.01.Hydroxytriamterene Sulfate and Triamterene in Plasma and Urine -- 11.11.Ibuprofen in Plasma )also Enantiomeric Separation( -- 11.21.Minocycline in Plasma -- 11.31.Norfloxacine in Plasma and Urine -- 11.41.Paclitaxel in Plasma, Urine and Tissue -- 11.51.Paracetamol )Acetaminophen( in Plasma -- 11.61.Pimelic Acid in Plasma and Urine -- 11.71.8-Prenylnaringenin in Plasma and Different Types of Tissues -- 11.81.Silibinin in Plasma -- 11.91.Valnemulin in Plasma, Different Tissue Types and in Animal Feed -- 11.02.Vitamin B1 )Total Thiamine( in Plasma -- Table 11.1 Recommended books -- Table 11.2 Properties of substances -- Appendix -- Short Description of Determination for about 001 Substances -- Substances listed in the Appendix

عنصر شناسه ای

، High performance liquid chromatography

عنصر شناسه ای

Analysis ، Drugs

عنصر شناسه ای

، Pharmaceutical technology

شماره

شماره رده

کد نقش

AU

عنصر شناسه اي

Hermann Mascher

عنصر شناسه اي

TI

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