1. Phosphatidylinositol 3-kinase signalling: a tale of two kinase activities / Paul J. Coffer -- 2. Mammalian MAP kinase pathways / John M. Kyriakis -- 3. Genetic approaches to protein kinase function in lower eukaryotes / Simon E. Plyte -- 4. Specificity in JAK-STAT signalling / Adrienne Halupa and Dwayne L. Barber -- 5. On the road to destruction: suppression of protein tyrosine kinase signalling by SOCS family proteins / Robert Rottapel, Subburaj Ilangumaran and Paulo de Sepulveda -- 6. Cyclin-dependent protein kinases / Kathleen L. Gould -- 7. Mechanisms and biology of signalling by serine/threonine kinase receptors form the TGF[beta] superfamily / Michael Kluppel, Pamela A. Hoodless and Jeffrey L. Wrana / [and others] -- 8. The ATM and DNA-PK proteins: the sensing, signalling, and repair of DNA damage / Robert Bristow, Hans Bluyssen and Annelies de Klein / [and others].