عنوان

How tobacco smoke causes disease :

(Number (ISBN

0160840783

(Number (ISBN

9780160840784

Number

b731308

Number

HE 20.2:T 55/2

Title Proper

How tobacco smoke causes disease :

General Material Designation

[Book]

Other Title Information

the biology and behavioral basis for smoking-attributable disease : a report of the Surgeon General.

Place of Publication, Distribution, etc.

Washington, DC :

Name of Publisher, Distributor, etc.

For sale by the Supt. of Docs., U.S. G.P.O.,

Date of Publication, Distribution, etc.

2010.

Specific Material Designation and Extent of Item

xv, 704 pages :

Other Physical Details

illustrations (some color) ;

Dimensions

28 cm

Text of Note

Includes bibliographical references and index.

Text of Note

1: Introduction, evaluation of evidence on mechanisms of disease production, and summary. Introduction ; Evaluation of evidence on mechanisms of disease production ; Mechanisms of action: necessary, sufficient, or neither ; Description of evidence on mechanisms of disease production ; Scientific basis of the report ; Development of the report ; Major conclusions ; Chapter conclusions ; References -- 2: The changing cigarette. Introduction ; Cigarette design changes over the years ; New cigarette products ; Low-nicotine cigarettes ; Cigarette-like products ; Evaluation of new cigarette products ; New oversight of tobacco products ; Summary ; Conclusions ; References -- 3: Chemistry and toxicology of cigarette smoke and biomarkers of exposure and harm. Introduction ; Chemistry ; Biomarkers ; Summary ; Conclusions ; References -- 4: Nicotine addiction : past and present. Introduction ; Definition of nicotine addiction ; Tobacco constituents and pharmacokinetics ; Components of nicotine addiction ; Pathophysiology of nicotine addiction ; Genetics ; Prevalence and trajectory toward nicotine dependence ; Epidemiology of tobacco use and nicotine dependence in adults ; Trajectory of recovery or relapse ; Evidence summary ; Conclusion ; References -- 5: Cancer. Introduction ; Carcinogen exposure, metabolism, and DNA adducts ; DNA repair and conversion of adducts to mutations ; Gene mutations in tobacco-induced cancer ; Loss of mechanisms for growth control ; Other aspects ; Evidence summary ; Conclusions ; References -- 6: Cardiovascular diseases. Introduction ; Tobacco use and cardiovascular disease ; Secondhand tobacco smoke and cardiovascular disease ; Pathophysiology ; Hemodynamic effects ; Smoking and the endothelium ; Thrombogenic effects ; Inflammation ; Smoking and diabetes ; Lipid abnormalities ; Cardiovascular biomarkers ; Smoking cessation and cardiovascular disease ; Methods to reduce exposure ; Evidence summary ; Conclusions ; References.

Text of Note

7: Pulmonary diseases. Introduction ; Smoking and respiratory defense mechanisms ; Oxidative stress ; Oxidative stress in chronic obstructive pulmonary disease ; Genetics of pulmonary disease and susceptibility to tobacco smoke ; Pathogenesis of emphysema ; Summary ; Evidence summary ; Conclusions ; Implications ; References -- 8: Reproductive and developmental effects. Introduction ; Review of epidemiologic literature on smoking ; Pathophysiological and cellular and molecular mechanisms of smoking ; Implications ; Evidence summary ; Conclusions ; References -- 9: A vision for the future. The global tobacco epidemic ; Reducing the risks from smoking ; Ending the tobacco epidemic ; Concluding remarks ; Appendix 9-1. Recommendations for future research ; Appendix 9-2. Ending the tobacco problem : a blueprint for the nation ; Appendix 9-3. Promoting healthy lifestyles : policy, program, and personal recommendations for reducing cancer risk ; References -- List of abbreviations -- List of tables and figures -- Definitions and alternative nomenclature of genetic symbols used in this report -- Index.

0

8

Text of Note

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Source for Acquisition/Subscription Address

GPO

Stock Number

017-023-00219-8

Terms of Availability

$66.00

Title

How tobacco smoke causes disease.

Parallel Title

Biology and behavioral basis for smoking-attributable disease

Parallel Title

Report of the Surgeon General

Smoking-- Health aspects.

Tobacco smoke pollution-- Health aspects.

Tobacco use-- Health aspects.

Disease-- etiology.

Smoking-- adverse effects.

Tobacco-- adverse effects.

Tobacco Smoke Pollution-- adverse effects.

Tobacco Use Disorder-- complications.

Smoking-- Health aspects.

Tobacco smoke pollution-- Health aspects.

Tobacco use-- Health aspects.

Number

Edition

Class number

Book number

Class number

Class number

Book Number

United States., Public Health Service., Office of the Surgeon General.

Date of Transaction

20201203145417.0

Electronic name

[Book]

Y