عنوان

Development of a New Heterocycle-Forming Reaction and Kinetic Resolution with N-Heterocyclic Carbenes /

(Number (ISBN

9789811393983

(Number (ISBN

9789811393990

(Number (ISBN

9789811394003

(Number (ISBN

9811393982

(Number (ISBN

9811393990

(Number (ISBN

9811394008

Erroneous ISBN

9789811393976

Erroneous ISBN

9811393974

Title Proper

Development of a New Heterocycle-Forming Reaction and Kinetic Resolution with N-Heterocyclic Carbenes /

General Material Designation

[Book]

First Statement of Responsibility

Yinli Wang.

Place of Publication, Distribution, etc.

Singapore :

Name of Publisher, Distributor, etc.

Springer,

Date of Publication, Distribution, etc.

2019.

Specific Material Designation and Extent of Item

1 online resource (118 pages)

Series Title

Springer Theses

Text of Note

"Doctoral thesis accepted by the University of Kyoto, Kyoto, Japan."

Text of Note

Introduction -- Oxa- and Azacycle-formation via Migrative Cyclization of Sulfonylalkynol and Sulfonylalkynamide -- Kinetic Resolution of #x1B;(Sa#x1B;(B-Hydroxy Carboxylic Acid Derivatives Based on Chiral Recognition of Substrate-Cocatalyst Complex -- Conclusion -- Experimental Section.

0

Text of Note

In this book, the author focuses on exploring new organocatalytic transformations under operationally simple and environmentally friendly reaction conditions. Two new types of catalytic reactions promoted by N-heterocyclic carbenes (NHCs) are described. The oxa- and azacycle-forming reactions of sulfonylalkynols and sulfonylalkynamides are broadly considered to be a new type of activation mode in NHC chemistry, wherein the bond formation with internal O- and N-nucleophiles occurs at the #x1B;(Sd#x1B;(B-position of the propargyl sulfones with 1,2-sulfonyl migration. The resulting oxa- and azacycles are core structures in many biologically significant compounds and medicinally important agents. In addition, the book develops the chiral NHC-catalyzed kinetic resolution of #x1B;(Sa#x1B;(B-hydroxy carboxylic acid derivatives based on chiral recognition of the substrate-cocatalyst complex. In this carboxylate cocatalyst-assisted chiral acylation, the reaction rate acceleration and selectivity enhancement are interpreted in terms of the reversible complexation of the substrate and carboxylate cocatalyst, which is verified by control experiments and measured using analytical methods. The findings described here reveal a promising new aspect of not only NHC catalysis but also identifying novel catalysis systems.

Source for Acquisition/Subscription Address

Springer Nature

Stock Number

com.springer.onix.9789811393983

Title

Development of a New Heterocycle-Forming Reaction and Kinetic Resolution with N-Heterocyclic Carbenes.

International Standard Book Number

9789811393976

Carbenes (Methylene compounds)

Heterocyclic chemistry.

Carbenes (Methylene compounds)

Heterocyclic chemistry.

PNN

PNN

SCI013040

Number

Number

Edition

Class number

Class number

Wang, Yinli.

Date of Transaction

20200823231509.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y