Strategies in Psychotropic Drug Innovation --;Receptor Subtypes and Endogenous Ligands: Rational Tools in the Search for Psychotropic Drugs? --;Histamine H3 Receptors in the Brain: Potent and Selective Ligands. --;Targets for Neurotransmitter Receptor Research Using PET Scan: The Neuroleptic Binding Site. --;The Potential of Positron-Emission Tomography for Pharmacokinetic and Pharmacodynamic Studies of Neuroleptics. --;Neurotransmitter Interactions as a Target of Drug Action. --;E-10-Hydroxynortriptyline: Effects and Disposition of a Potential Novel Antidepressant. --;Molecular Graphics of Antidepressant Drugs and Metabolites. --;Negative Symptoms in Schizophrenia: A Target for New Drug Development. --;Clinical Significance of Receptor-Selective Drugs --;Clinical Effects of Selective Serotonin Reuptake Inhibitors. --;Effects of Serotonergic Agonists on Neuroendocrine Responses of Rhesus Monkeys and Patients with Depression and Anxiety Disorders. --;Theoretical and Practical Implications of a Controlled Trial of an?2-Adrenoceptor Antagonist in the Treatment of Depression. --;Selective Dopamine Dt and D2 Receptor Antagonists. --;Animal Pharmacology of Raclopride, a Selective Dopamine D2 Antagonist. --;Benzodiazepine Receptor Subtypes and Their Possible Clinical Significance. --;Pharmacogenetics in Psychopharmacology --;Genetic Polymorphisms of Drug-Metabolizing Enzymes: Molecular Mechanisms. --;Genetic Polymorphism in Drug Oxidation. --;The Use of Human Liver Banks in Pharmacogenetic Research. --;Inhibitors of the Microsomal Oxidation of Psychotropic Drugs: Selectivity and Clinical Significance. --;Pharmacogenetics of Antidepressants. --;Pharmacokinetic and Clinical Significance of Genetic Variability in Psychotropic Drug Metabolism. --;Inhibition of Desipramine 2-Hydroxylation by Quinidine and Quinine in Rapid and Slow Debrisoquine Hydroxylators. --;Debrisoquine Oxidation Phenotype in Psychiatric Patients. --;Role of Pharmacogenetics in Drug Development. --;Clinical Significance of Pharmacokinetic Variability --;Clinical Implications of the Pharmacokinetics of Tricyclic Antidepressants. --;Detection of Populations at Risk Using Drug Monitoring Data. --;Hydroxy Metabolites of Tricyclic Antidepressants: Evaluation of Relative Cardiotoxicity. --;Therapeutic Drug Monitoring of Tricyclic Antidepressants: A Means of Avoiding Toxicity. --;Neuroleptic Drug Levels in Erythrocytes and in Plasma: Implications for Therapeutic Drug Monitoring. --;Active Metabolites of Neuroleptics in Plasma and CSF: Implications for Therapeutic Drug Monitoring. --;Hydroxyhaloperidol and Clinical Outcome in Schizophrenia. --;Plasma Level Monitoring for Maintenance Neuroleptic Therapy. --;Perphenazine Serum Levels in Patients on Standard Doses. --;Dose-Finding Problems with Psychotropic Drugs --;From Animal Experiments to Clinical Dosing: Some Aspects of Preclinical Development of Antidepressants. --;Evaluation of Clinical and Biological Parameters in Healthy Volunteers: More than Pharmacokinetics and Side Effects? --;Dose Finding and Serum Concentrations of Neuroleptics in the Treatment of Schizophrenic Patients. --;Post-Marketing Surveillance of Psychotropic Drugs. --;List of Participants.
SUMMARY OR ABSTRACT
Text of Note
This volume collects the invited lectures and some selected contributions presented at the 5th International Meeting on Clinical Pharmacology in Psychiatry, which was held 26-30 June 1988 at the University of Troms0, Norway. The earlier conferences have been documented in Clinical Pharmacology in Psychiatry, edited by E.