عنوان

Bioinformatics of non small cell lung cancer and the ras proto-oncogene

(Number (ISBN

9789814585071

(Number (ISBN

9789814585088

(Number (ISBN

9814585076

(Number (ISBN

9814585084

Number

b538881

Title Proper

Bioinformatics of non small cell lung cancer and the ras proto-oncogene

General Material Designation

[Book]

First Statement of Responsibility

Amita Kashyap, D. Bujamma, Naresh Babu M.

Place of Publication, Distribution, etc.

Heidelberg

Name of Publisher, Distributor, etc.

Springer-Verlag

Date of Publication, Distribution, etc.

[2015] 2015

Specific Material Designation and Extent of Item

(1 recurs electrònic (vii, 72 pàgines)) : il·lustracions (algunes color)

Series Title

SpringerBriefs in applied sciences and technology., Forensic and medical bioinformatics.

Text of Note

Descripció del recurs: el 2 de març de 2016.

Text of Note

Conté: Introduction --;Review of Literature --;Materials and Methods (Tools and Databases) --;Flowchart --;Conclusion.-References

Text of Note

Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10-30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.

Bioinformàtica.

Oncogens Ras.

Pulmons -- Càncer.

Class number

Book number

Amita Kashyap, D. Bujamma, Naresh Babu M.

Amita Kashyap

D Bujamma

Naresh Babu M

Electronic name

[Book]

Y