عنوان

Genome editing :

(Number (ISBN

1493935097

(Number (ISBN

9781493935093

Erroneous ISBN

9781493935079

Number

dltt

Title Proper

Genome editing :

General Material Designation

[Book]

Other Title Information

the next step in gene therapy /

First Statement of Responsibility

Toni Cathomen, Matthew Hirsch, Matthew Porteus, editors

Specific Material Designation and Extent of Item

1 online resource (xvi, 263 pages) :

Other Physical Details

illustrations (some color).

Series Title

Advances in experimental medicine and biology,

Volume Designation

volume 895

ISSN of Series

0065-2598 ;

Text of Note

Includes index

Text of Note

1. Gene Editing: Double-Strand Break Induced Gene Targeting and Mutagenesis 20 Years Later -- 2. The Development and Use of Zinc-Finger Nucleases -- 3.The Use and Development of TAL Effector Nucleases -- 4. Genome Editing for Neuromuscular Diseases -- 5. Phage Integrases for Genome Editing -- 6. Precise Genome Modification Using Triplex Forming Oligonucleotides and Peptide Nucleic Acids -- 7. Genome Editing by Aptamer-Guided Gene Targeting -- 8. Stimulation of AAV Gene Editing via DSB Repair -- 9. Engineered Nucleases and Trinucleotide Repeat Diseases -- 10. Using Engineered Nucleases to Create HIV-Resistant Cells -- 11. Strategies to Determine Off-Target Effects of Engineered Nucleases

0

Text of Note

This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genome editing for neuromuscular diseases, phase integrases, triplex forming oligonucleotides and peptide nucleic acids, aptamer-guided gene targeting, AAV gene editing via DSB repair, engineered nucleases and trinucleotide repeat diseases, and creation of HIV-resistant cells. The expertly authored chapters contextualize current developments within the history of genome editing while also discussing the current and potential safety concerns of this rapidly growing field. Genome Editing: The Next Step in Gene Therapy, the latest volume in the American Society of Gene and Cell Therapy series, deftly illuminates the potential of genetic engineering technology to eradicate today's deadliest and most prolific diseases. It is ideal reading for clinicians and researchers in genetics and immunology.

Gene therapy.

Genetic engineering.

MED107000

MFN

SCI-- 013060

TEC-- 009010

Number

Edition

Class number

Cathomen, Toni

Hirsch, Matthew

Porteus, Matthew H.

Ohio Library and Information Network.

Date of Transaction

20201222040530.1

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

270410

Y