عنوان

Numerical modeling of COVID-19 neurological effects

(Number (ISBN

9781003243052

(Number (ISBN

9781032152110

Number

E3295

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

Numerical modeling of COVID-19 neurological effects

General Material Designation

[Electronic book]

Other Title Information

: ODE/PDE analysis in R

First Statement of Responsibility

/ William Schiesser.

Place of Publication, Distribution, etc.

Boca Raton

Name of Publisher, Distributor, etc.

: CRC Press

Date of Publication, Distribution, etc.

, 2021.

Specific Material Designation and Extent of Item

1 v.

Other Physical Details

; ill.

Text of Note

William E. Schiesser is Emeritus McCann Professor of Computational Biomedical Engineering, Chemical and Biomolecular Engineering and Professor of Mathematics at Lehigh University. His research is directed toward numerical methods and associated software for ordinary, differential-algebraic and partialdifferential equations (ODE/DAE/PDEs), and the development of mathematical models based on ODE/DAE/PDEs. He is the author, coauthor or coeditor of 30+ books, and his ODE/DAE/PDE computer routines have been accessed by thousands of colleges and universities, corporations and government agencies

Text of Note

Covid-19 is primarily a respiratory disease which results in impaired oxygenation of blood. The O2-deficient blood then moves through the body, and for the study in this book, the focus is on the blood flowing to the brain. The dynamics of blood flow along the brain capillaries and tissue is modeled as systems of ordinary and partial differential equations (ODE/PDEs). The ODE/PDE methodology is presented through a series of examples, 1. A basic one PDE model for O2 concentration in the brain capillary blood. 2. A two PDE model for O2 concentration in the brain capillary blood and in the brain tissue, with O2 transport across the blood brain barrier (BBB). 3. The two model extended to three PDEs to include the brain functional neuron cell density. Cognitive impairment could result from reduced neuron cell density in time and space (in the brain) that follows from lowered O2 concentration (hypoxia). The computer-based implementation of the example models is presented through routines coded (programmed) in R, a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The PDE analysis is based on the method of lines (MOL), an established general algorithm for PDEs, implemented with finite differences. The routines are available from a download link so that the example models can be executed without having to first study numerical methods and computer coding. The routines can then be applied to variations and extensions of the blood/brain hypoxia models, such as changes in the ODE/PDE parameters (constants) and form of the model equations

COVID-19 (Disease) -- Mathematical models

Neurologic manifestations of general diseases

Class number

Book number

Schiesser, W. E., author.

Country

Iran

Agency

University of Tehran. Library of College of Science

Date of Transaction

20221101

Date and Hour of Consultation and Access

UT_SCI_BL_DB_1003601_0001.pdf

e

BL

278840

1

a

Y