عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TLpq304130748
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
Effect of dietary ethanol on atherosclerosis in rabbits
نام عام مواد
[Thesis]
نام نخستين پديدآور
E. F. Wilson
نام ساير پديدآوران
R. L. Engen
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
Iowa State University
تاریخ نشرو بخش و غیره
1994
مشخصات ظاهری
نام خاص و کميت اثر
160
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
Ph.D.
کسي که مدرک را اعطا کرده
Iowa State University
امتياز متن
1994
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
The effect of dietary ethanol on atherosclerotic regression and vasoconstriction in atherosclerotic rabbits was addressed by feeding male New Zealand white rabbits (n = 19) a diet enriched with 0.8% cholesterol for 45 days, followed by randomization to one of three diets for the next 45 days: (1) Continued consumption of a cholesterol-rich diet (CC; n = 6), (2) Consumption of a cholesterol-free diet (CF; n = 6), and (3) Consumption of a cholesterol-free diet supplemented with ethanol in the drinking water (10% v/v; ECF; n = 7). Atherosclerosis and vasoconstrictive properties of the aortas were evaluated on day 90. Data are expressed as mean SEM, means with the same letter are not significantly (P < 0.05) different. Total plasma cholesterol of the CC, CF and ECF groups were 1532 107.01A, 440.50 44.08B and 957.79 157.21 mg/dl', respectively. Plasma triglyceride concentrations of the CC, CF and ECF groups were 238.97 64.28A, 79.97 11.77A and 433.32 122.07B mg/dl, respectively. No significant differences were noted in regards to the percent of aortic surface covered by Sudan-IV staining lesions, fatty streak areas in aortic cross-sections, smooth muscle area or aortic cholesterol content. Neither the CF nor the ECF diets promoted atherosclerotic regression. The total liver cholesterol content of the CC, CF and ECF groups were 3.98 0.33A, 2.36 0.30B and 1.97 0.31B grams cholesterol/liver, respectively. Norepinephrine (10M) promoted maximal contractile forces in the CC, CF and ECF groups of 3.69 0.32A, 5.09 0.39B and 5.31 0.30B grams, respectively. Potassium chloride (80 mM) promoted maximal contractile forces in the CC, CF and ECF groups of 4.01 0.35A, 5.04 0.38B and 5.34 0.47 gramsB respectively. The contractile forces developed in response to 200 mg/dl ethanol by the CC, CF and ECF groups were 51.4 7.5A, 71.2 12.6A and 104.9 31.5A, respectively. Serotonin (10M) developed contractile forces in the CC, CF and ECF groups of 2.35 0.24A, 2.13 0.21A and 2.89 0.59A grams, respectively. This investigation demonstrated that the inclusion of dietary ethanol as part of a lipid lowering diet in atherosclerotic rabbits is associated with the maintenance of risk factors promoting with vasospasm and continued atherogenesis.
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Anatomy & physiology
موضوع مستند نشده
Animals
موضوع مستند نشده
Biological sciences
موضوع مستند نشده
Health and environmental sciences
موضوع مستند نشده
Nutrition
موضوع مستند نشده
Surgery
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
E. F. Wilson
مستند نام اشخاص تاييد نشده
R. L. Engen
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
