Chemometric optimization and kinetic developments in flow injection analysis
نام عام مواد
[Thesis]
نام نخستين پديدآور
F. E. O. Suliman
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
King Fahd University of Petroleum and Minerals (Saudi Arabia)
تاریخ نشرو بخش و غیره
1996
مشخصات ظاهری
نام خاص و کميت اثر
235
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
Ph.D.
کسي که مدرک را اعطا کرده
King Fahd University of Petroleum and Minerals (Saudi Arabia)
امتياز متن
1996
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Chemometric optimization methodologies have been utilized for the development of quantitative methods of analysis of some drugs using flow injection (FI) techniques. Super modified simplex procedures together with statistical design techniques have been used for optimization and modeling of response surface. The sequential optimization has validated the flow injection methods proposed with excellent reproducibility, high sensitivity, and a wide dynamic range. A sampling frequency of not less than 120 h was obtained for all methods developed. Sequential injection (SI) technique has been successfully applied for the determination of reaction stoichiometry and formation constant. The 1:1 and 1:2 metal:drug mole ratio have been obtained for the complexation of some phenothiazines with palladium(II) in hydrochloric acid media and for the complexation of some flouroquinolones with iron(III) in sulfuric acid media respectively. For the first time, sequential injection technique has been employed for full kinetics investigation resulting in proposing reasonable mechanism of reactions and adopting kinetic methods of analysis. The complexation reaction of bromazepam with iron(II) was studied in hydrochloric acid media. The orders of the reaction with respect to each reactant were determined and a consistent reaction rate law was offered.
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Analytical chemistry
موضوع مستند نشده
Analytical chemistry
موضوع مستند نشده
bromazepam
موضوع مستند نشده
Pharmacology
موضوع مستند نشده
Pure sciences
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )