Characterization and Evolution of Intracellular Survival in Bordetella
نام عام مواد
[Thesis]
نام نخستين پديدآور
Rivera, Israel
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
University of Georgia
تاریخ نشرو بخش و غیره
2020
مشخصات ظاهری
نام خاص و کميت اثر
170
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
Ph.D.
کسي که مدرک را اعطا کرده
University of Georgia
امتياز متن
2020
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
The classical bordetellae possess several partially characterized virulence mechanisms that are studied in the context of a complete extracellular life cycle in their mammalian host. Yet, classical bordetellae have repeatedly been reported within dendritic cells and alveolar macrophages in clinical samples, and in vitro experiments convincingly demonstrate that the bacteria can survive intracellularly within mammalian phagocytic cells, an ability that appears to have descended from ancestral progenitor species that lived in the environment and acquired the mechanisms to resist unicellular phagocytic predator. Many pathogens, including Mycobacterium tuberculosis, Salmonella enterica, Francisella tularensis, and Legionella pneumophila are known to parasitize and multiply inside eukaryotic host cells. This strategy provides protection, nutrients, and the ability to disseminate systemically. While some work has been dedicated at characterizing B. pertussis intracellular survival phenotype, there is very little understanding of how this strategy has evolved within the genus Bordetella and contributes to bacterial pathogenicity, evasion of host immunity and systemic dissemination. Here, we explore the mechanisms that control the changes accompanying intracellular survival and how these have been acquired and conserved throughout the divergent evolutionary histories of Bordetella species.
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Bioinformatics
موضوع مستند نشده
Microbiology
موضوع مستند نشده
Molecular biology
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )