عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TL58175
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
Fenolik asitlerin varlığında patojen bakterilerin moleküler incelemesi
نام عام مواد
[Thesis]
نام نخستين پديدآور
Özdemir, Özgün Öykü
نام ساير پديدآوران
Soyer, Ferda
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
Izmir Institute of Technology (Turkey)
تاریخ نشرو بخش و غیره
2019
يادداشت کلی
متن يادداشت
236 p.
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
Ph.D.
کسي که مدرک را اعطا کرده
Izmir Institute of Technology (Turkey)
امتياز متن
2019
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Pathogenic bacteria, including P. aeruginosa, are serious threats for human health with their antibiotic resistance and virulence factors. Since phenolic acids, secondary metabolites of plants, can be good candidates as antimicrobial agents, their mode of action should be investigated. Proteomics is one of the main approaches for elucidating the mode of action of such compounds. In addition, in order to enhance the antimicrobial effects and stabilities of phenolics, they can be encapsulated into nanoparticles. The nanoparticles can be produced from chitosan and alginate which are biocompatible polymers. In this study, the antimicrobial effects of 3-HPAA and 4-HBA were presented with MIC values of 2.1 and 1.9 mg/ml, respectively. The bacteriocidal effects of them were also shown as 2.3 mg/ml for 3-HPAA and 2.1 mg/ml for 4-HBA. The morphological changes of bacteria were determined after phenolic acid exposure via SEM. The LC-ESI-MS/MS technique was used to show changes in the protein profile of bacteria arose from antimicrobial effects. Both phenolic exposures resulted in various protein changes especially in membrane-related proteins as well as ribosome and protein synthesis related-proteins. In addition, they caused serious oxidative stress depending on the protein profile changes related to redox proteins. Alginate-chitosan nanoparticles resulted increased antimicrobial effects of the phenolics which were produced, characterized and tested on various pathogenic bacteria via agar diffusion and spectrophotometric measurements. Hence, free or encapsulated forms of phenolic acids were demonstrated as effective antimicrobial agents and based on proteomic results, the effect of phenolic acids may be multi targeted.
اصطلاحهای موضوعی کنترل نشده
اصطلاح موضوعی
Bacterial infections
اصطلاح موضوعی
Drug resistance
اصطلاح موضوعی
Food contamination & poisoning
اصطلاح موضوعی
Molecular biology
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
Özdemir, Özgün Öykü
نام شخص - ( مسئولیت معنوی درجه دوم )
مستند نام اشخاص تاييد نشده
Soyer, Ferda
شناسه افزوده (تنالگان)
مستند نام تنالگان تاييد نشده
Izmir Institute of Technology (Turkey)
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
