عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TL58114
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
Farklı gözenek özelliklerine sahip farklı boyutlardaki mezoporlu silika nanoparçacıkların zeta potansiyelinin deneysel ve nümerik incelenmesi
نام عام مواد
[Thesis]
نام نخستين پديدآور
Yakın, Fetiye
نام ساير پديدآوران
Barışık, Murat
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
Izmir Institute of Technology (Turkey)
تاریخ نشرو بخش و غیره
2020
يادداشت کلی
متن يادداشت
72 p.
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
Master's
کسي که مدرک را اعطا کرده
Izmir Institute of Technology (Turkey)
امتياز متن
2020
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Mesoporous silica nanoparticles (MSN) are utilized by many applications due to their high surface to volume ratio, tunable pore size, low toxicology, and colloidal stability. These properties make silica nanoparticles good candidates for targeted drug delivery applications. Targeted drug delivery steps include cellular internalization, endosomal escape, and cargo release to the selective tissue. The geometric properties of MSN such as particle size, pore size, and porosity, as well as surface chemistry and resulting surface charge density determine the MSN behavior in these steps. This study examines the influence of particle size, pore size, and porosity of an MSN to its surface zeta potential. We performed both numerical and experimental investigations. The zeta potential of various MSNs at different salt concentrations was calculated by solving the Poisson-Nernst-Planck equation with active surface charge boundary conditions considering surface chemistry. We validated our multi-ion model through experiments. Results indicate that zeta potential exhibits a strong dependence on particle size, pore size, and porosity. By increasing porosity and/or pore size, the absolute average zeta potential decreased up to 25% from the theoretical predictions. Second, zeta potentials of silica particles at different sizes and surface areas were experimentally measured at different salt concentrations. Particles were systematically characterized by measuring particle size using Dynamic Light Scattering (DLS), analyzing chemical properties using Fourier-transform infrared spectroscopy (FTIR), measuring surface area using Brunauer- Emmett-Teller (BET) analysis, and imaging using Scanning Electron Microscopy (SEM). A well-dispersed solution in colloidal stability was obtained by systematically tuning corresponding parameters. The absolute average zeta potential was found to increase with a decrease in particle size, while zeta potential was found to decrease with a decrease in surface area at a constant particle diameter, similar to numerical calculations.
اصطلاحهای موضوعی کنترل نشده
اصطلاح موضوعی
Biomedical engineering
اصطلاح موضوعی
Catalysis
اصطلاح موضوعی
Enzymes
اصطلاح موضوعی
Laboratories
اصطلاح موضوعی
Morphology
اصطلاح موضوعی
Nanomaterials
اصطلاح موضوعی
Nanoparticles
اصطلاح موضوعی
Pore size
اصطلاح موضوعی
Surfactants
اصطلاح موضوعی
Toxicology
اصطلاح موضوعی
Tumors
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
Yakın, Fetiye
نام شخص - ( مسئولیت معنوی درجه دوم )
مستند نام اشخاص تاييد نشده
Barışık, Murat
شناسه افزوده (تنالگان)
مستند نام تنالگان تاييد نشده
Izmir Institute of Technology (Turkey)
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
