عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TL57947
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
Adsorptive Surface Modification of Cellulose Nanocrystals to Stabilize Nutraceuticals Loaded Lipid Carriers for Food Application
نام عام مواد
[Thesis]
نام نخستين پديدآور
Patel, Avinash Singh
نام ساير پديدآوران
Camire, Mary E.
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
The University of Maine
تاریخ نشرو بخش و غیره
2020
يادداشت کلی
متن يادداشت
203 p.
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
Ph.D.
کسي که مدرک را اعطا کرده
The University of Maine
امتياز متن
2020
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Lipid carriers such as emulsions and liposomes have been widely studied as carriers for different nutraceuticals. However, lipid carriers' physicochemical instability results in the leakage of loaded nutraceuticals and the low solubility into the digestion medium, thus reducing the bioaccessibility. Cellulose nanocrystals (CNC) are nano-sized cellulose derivatives obtained after hydrolysis of cellulosic matrices that possess potential applications in functional foods and nutraceuticals. However, hydrophilicity, anionic surface potential, and poor re-dispersibility limit CNC's applications. The primary objectives of this research were 1) to modify CNC via adsorbing polyethylene glycol (PEG) to stabilize liposomes and to study its physiochemical stability at different in vitro gastrointestinal tract (GIT) conditions, pH levels (1-11), temperatures (4-100°C) and illumination periods (4-72 hours); 2) to modify CNC via adsorbing lauric acid to stabilize O/W emulsion and to study its physicochemical stability at different pH (1-11), dilution factors (1-10 times), storage period (up to 30 days) and GIT conditions. Phycobiliprotein and beta-carotene were chosen as model nutraceuticals. In study 1, particle size and microscopic analysis revealed a better physical/kinetic stability for the liposomes stabilized with PEG-adsorbed CNC than the liposomes stabilized with unmodified CNC, resulting in significantly (p≤0.05) smaller average particle size during the initial and mouth phases of the in vitro GIT study, nonetheless a significant (p≤0.05) increase in the particle size from ~300 nm to ~5500 nm at gastric phase due to lower pH. Moreover, stabilized liposomes retained the attributes of phycobiliprotein against pH, illumination, and a temperature of 60 °C. In study 2, lauric acid-adsorbed CNC affirmed the kinetic/physical stability of emulsions throughout the GIT phases. Results exhibited a maximum of 65% beta-carotene bioaccessibility for the emulsion stabilized with modified CNC, and 71% for the emulsion stabilized with unmodified CNC. Moreover, a higher amount of lipid oxidation was recorded for the emulsion with stabilized modified CNC than the emulsion stabilized with gum Arabic. Although modified CNC retains the kinetic/physical stability of lipid carriers; however, it increases lipid carriers' chemical instability and decreases the loaded nutraceuticals' bioaccessibility. A strategic modification of CNC is needed to ensure the stability of lipid carriers and increased nutraceuticals bioaccessibility.
اصطلاحهای موضوعی کنترل نشده
اصطلاح موضوعی
Cellulose
اصطلاح موضوعی
Chemistry
اصطلاح موضوعی
Fatty acids
اصطلاح موضوعی
Food science
اصطلاح موضوعی
Morphology
اصطلاح موضوعی
Nanocrystals
اصطلاح موضوعی
Nanoparticles
اصطلاح موضوعی
Proteins
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
Patel, Avinash Singh
نام شخص - ( مسئولیت معنوی درجه دوم )
مستند نام اشخاص تاييد نشده
Camire, Mary E.
شناسه افزوده (تنالگان)
مستند نام تنالگان تاييد نشده
The University of Maine
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
