عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TL54693
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
Exploring the Role of Genetics and Epigenetics in the Response to Conflict-Related Violence
نام عام مواد
[Thesis]
نام نخستين پديدآور
Clukay, Christopher J.
نام ساير پديدآوران
Mulligan, Connie J.
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
University of Florida
تاریخ نشرو بخش و غیره
2020
يادداشت کلی
متن يادداشت
162 p.
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
Ph.D.
کسي که مدرک را اعطا کرده
University of Florida
امتياز متن
2020
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Psychosocial stress, the physical and mental stress resulting from disruptive social forces, substantially impacts human health. Within this category, exposure to conflict-related violence is particularly concerning due to its intensity and the number of people affected. In this dissertation, I explore how genetics may impact the human response to stress and how stress may impact epigenetic variation in two populations exposed to conflict-related violence. Genetic variation may cause differences in stress perception or response. As such, in the first study (Ch. 2 and 3), I explored the effect of genotype on the human response to psychosocial stress among Syrian refugee youth. Utilizing samples from a collaboration (n = 398), I extracted DNA and assayed for genetic variants in four candidate genes; FAAH, SLC6A4, BDNF, and COMT. Variants were tested for associations with five measures of stress and psychosocial health using longitudinal mixed effects modeling. After multiple testing correction, I observed an association between COMT genotype and perceived stress in males and interactions with resilience in association with multiple measures in females. In the second study (Ch. 4 and 5), I examined the impact of psychosocial stress on epigenetic variation, specifically DNA methylation (DNAm), and health among mother-infant dyads in the Democratic Republic of the Congo. Using principal component analysis to summarize DNAm at a given gene, I tested DNAm at methylation complex genes, whose products control genome-wide DNAm, for associations with stress, genome-wide mean methylation (GMM), and birthweight. I observed multiple associations between GMM and DNAm at methylation complex genes, suggesting that altered GMM may be linked to altered methylation complex regulation. I then analyzed DNAm throughout the genome by grouping and testing CpG sites at individual, regional, and genome-wide levels. While testing individual CpG sites revealed no significant associations with maternal stress, multiple associations were observed at regional and genome-wide levels, with responses differing between mothers and newborns. This dissertation highlights the complexities associated with the human response to stress and suggests possible molecular mechanisms related that response. It is hoped that future studies will continue to explore these effects to better understand how the environment impacts human health.
اصطلاحهای موضوعی کنترل نشده
اصطلاح موضوعی
Genetics
اصطلاح موضوعی
Health sciences
اصطلاح موضوعی
Social psychology
اصطلاح موضوعی
South Asian studies
اصطلاح موضوعی
Sub Saharan Africa studies
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
Clukay, Christopher J.
نام شخص - ( مسئولیت معنوی درجه دوم )
مستند نام اشخاص تاييد نشده
Mulligan, Connie J.
شناسه افزوده (تنالگان)
مستند نام تنالگان تاييد نشده
University of Florida
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
