Regulatory Role of Bile Acids in Dietary Fat Absorption and Intestinal Lipoprotein Production
نام عام مواد
[Thesis]
نام نخستين پديدآور
Stankovic, Bogdan
نام ساير پديدآوران
Adeli, Khosrow
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
University of Toronto (Canada)
تاریخ نشرو بخش و غیره
2019
يادداشت کلی
متن يادداشت
88 p.
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
M.Sc.
کسي که مدرک را اعطا کرده
University of Toronto (Canada)
امتياز متن
2019
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Postprandial dyslipidemia is a key feature of insulin resistance that involves the overproduction of chylomicrons from the intestine after a meal, resulting in an excess number of atherogenic lipoprotein remnants. Bile acids have been recognized as signaling molecules with the ability to regulate peripheral lipid metabolism and energy expenditure. Here I examined the utility of intraduodenal bile acid administration for lowering postprandial lipemia and chylomicron production in the Syrian golden hamster model. Bile acid administration was shown to decrease postprandial lipemia by slowing down gastric emptying and decreasing mRNA expression of genes involved in fatty acid absorption and chylomicron assembly. Furthermore, bile acid administration was able to regulate VLDL secretion in the fasting state and decreased postprandial lipemia in insulin resistant hamsters. Altogether, the findings arising from these studies support the potential utility of targeting bile acid receptors in the treatment of postprandial dyslipidemia often seen in insulin resistant states.
اصطلاحهای موضوعی کنترل نشده
اصطلاح موضوعی
Biology
اصطلاح موضوعی
Health sciences
اصطلاح موضوعی
Physiology
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )