عنوان

Mitochondrial inhibitors and neurodegenerative disorders /

شابک

1468498215

شابک

1592596924

شابک

9781468498219

شابک

9781592596928

شابک اشتباه

089603805X

شابک اشتباه

9780896038059

شابک اشتباه

9781592596928

شماره

b754273

عنوان اصلي

Mitochondrial inhibitors and neurodegenerative disorders /

نام عام مواد

[Book]

نام نخستين پديدآور

edited by Paul R. Sanberg, Hitoo Nishino, Cesario V. Borlongan.

محل نشرو پخش و غیره

Totowa, N.J. :

نام ناشر، پخش کننده و غيره

Humana Press,

تاریخ نشرو بخش و غیره

©2000.

نام خاص و کميت اثر

1 online resource (xvii, 313 pages) :

ساير جزييات

illustrations

عنوان فروست

Contemporary neuroscience

متن يادداشت

Includes bibliographical references and index.

متن يادداشت

Mitochondrial Inhibitors and Neurodegenerative Disorders -- Foreword -- Preface -- Contents -- Contributors -- PART I. Mitochondrial Toxins: Symptomatology, Origin, and Chemistry -- 1 Clinical Manifestations and Mechanisms of Action of Environmental Mitochondrial Toxins -- 2 History of 3-Nitropropionic Acid: Occurrence and Role in Human and Animal Disease -- 3 The Neurochemistry of 3-Nitropropionic Acid -- PART II. Mitochondrial Dysfunctions: Models of Neurodegeneration and Mechanisms of Action -- 4 In Vitro Studies of 3-Nitropropionic Acid

متن يادداشت

11 Mechanisms of Action of 3-Nitropropionic Acid: Dopamine Overflow and Vulnerability of the Lateral Striatal Artery12 Mitochondrial Inhibition and Neuronal Death in Huntington�s Disease -- 13 Effects of Brain Mitochondrial Metabolism, Aging, and Caloric Restriction on Membrane Lipids and Proteins: An Electron Paramagnetic Resonance Investigation -- 14 Malonate: Profile and Mechanisms of Striatal Toxicity -- 15 Malonic Acid and the Chronic Administration Model of Excitotoxicity -- 16 Sodium Azide-Induced Neurotoxicity

متن يادداشت

5 Cognitive and Motor Deficits Produced by Acute and Chronic Administration of 3-Nitropropionic Acid in Rats6 Comparative Study on 3-Nitropropionic Acid Neurotoxicity -- 7 Mechanisms of 3-Nitropropionic Acid Neurotoxicity -- 8 Gender-Related Difference of the Effect of 3-Nitropropionic Acid on Striatal Artery -- 9 Variable Susceptibility to Neurotoxicity of Systemic 3-Nitropropionic Acid -- 10 The 3-Nitropropionic Acid Model of Huntington�s Disease: Do Alterations in the Expression of Metabolic mRNAs Predict the Development of Striatal Pathology?

متن يادداشت

PART III. Treatment Interventions for Mitochondrial-Induced Neurotoxicity17 Neuroprotective Strategies Against Cellular Hypoxia -- 18 Neuroprotective Effect of Perinatal Hypoxia Against 3-Nitropropionic Acid Neurotoxicity -- 19 Neural Transplantation and Huntington�s Disease: What Can We Learn from the 3-Nitropropionic Acid Model? -- 20 Neuroprotective Strategies in Parkinson�s Disease and Huntington�s Chorea: MPTP- and 3-NPA-Induced Neurodegeneration as Models -- Index

بدون عنوان

0

بدون عنوان

8

بدون عنوان

8

بدون عنوان

8

متن يادداشت

In Mitochondrial Inhibitors and Neurodegenerative Disorders, respected investigators from around the world critically review what is known about the role of mitochondrial inhibitors in cell death and the onset of neurodegeneration. These distinguished researchers-many pioneers in the field-detail the symptomatology, origin, and chemistry of mitochondrial toxins, and discuss animal models of human diseases related to abnormal mitochondrial function. The book focuses on 3-nitropropionic acid (3-NP) and its ability to replicate the cellular, anatomical, and behavioral alterations seen in Huntington's disease, and demonstrates that mitochondrial inhibitors play an important role in the etiology of central nervous system disorders. In addition, recent therapeutic modalities aimed at rescuing the central nervous system from abnormal functioning by mitochondria are discussed. With its timely, in-depth review, Mitochondrial Inhibitors and Neurodegenerative Disorders offers today's advanced investigators powerful insights into how mitochondrial toxins precipitate and exacerbate neurodegenerative disorders, and details important new treatment strategies that can halt or reverse disease progression.

متن يادداشت

Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.

عنوان

Mitochondrial inhibitors and neurodegenerative disorders.

موضوع مستند نشده

Mitochondrial pathology.

موضوع مستند نشده

Nervous system-- Degeneration-- Animal models.

موضوع مستند نشده

Nervous system-- Degeneration-- Pathophysiology.

موضوع مستند نشده

Neurotoxic agents.

موضوع مستند نشده

Mitochondria-- metabolism.

موضوع مستند نشده

Neurodegenerative Diseases-- chemically induced.

موضوع مستند نشده

Neurotoxins-- toxicity.

موضوع مستند نشده

Propionates-- toxicity.

موضوع مستند نشده

Aufsatzsammlung

موضوع مستند نشده

HEALTH & FITNESS-- Diseases-- Nervous System (incl. Brain)

موضوع مستند نشده

Krankheit

موضوع مستند نشده

MEDICAL-- Neurology.

موضوع مستند نشده

Mitochondrial pathology.

موضوع مستند نشده

Mitochondriopathie

موضوع مستند نشده

Nervensystem

موضوع مستند نشده

Nervous system-- Degeneration-- Pathophysiology.

موضوع مستند نشده

Neurotoxic agents.

موضوع مستند نشده

Propionsäure

موضوع مستند نشده

HEA-- 039110

موضوع مستند نشده

MED-- 056000

موضوع مستند نشده

PSAN

موضوع مستند نشده

PSAN

شماره

ويراست

شماره رده

نشانه اثر

شماره رده

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

Borlongan, Cesario V.

مستند نام اشخاص تاييد نشده

Nishino, Hitoo.

مستند نام اشخاص تاييد نشده

Sanberg, Paul R.

تاريخ عمليات

20201204135634.0

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y