عنوان

Streptomyces in nature and medicine :

شابک

0199722285

شابک

128115895X

شابک

1429493100

شابک

9780199722280

شابک

9781281158956

شابک

9781429493109

شابک اشتباه

019515066X

شابک اشتباه

9780195150667

شماره

b745459

عنوان اصلي

Streptomyces in nature and medicine :

نام عام مواد

[Book]

ساير اطلاعات عنواني

the antibiotic makers /

نام نخستين پديدآور

David A. Hopwood.

محل نشرو پخش و غیره

New York :

نام ناشر، پخش کننده و غيره

Oxford University Press,

تاریخ نشرو بخش و غیره

2007.

تاریخ نشرو بخش و غیره

©2007

نام خاص و کميت اثر

1 online resource (viii, 250 pages, 8 unnumbered pages of plates) :

ساير جزييات

illustrations (some color)

متن يادداشت

Includes bibliographical references (pages 229-240) and index.

متن يادداشت

Actinomycetes and antibiotics -- Antibiotic discovery and resistance -- Microbial sex -- Towards gene cloning -- From chromosome map to DNA sequence -- Bacteria that develop -- The switch to antibiotic production -- Unnatural natural products -- Functional genomics -- Genomics against tuberculosis and leprosy.

بدون عنوان

0

متن يادداشت

This is an insider's account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes - the actinomycetes - were discovered in the latter part of the nineteenth century, but remained a 'Cinderella' group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic after penicillin to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium.; There follow chapters in which the intricate molecular machinery that adapts the organisms' metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then comes an up-to-the minute account of the use of genetic engineering to make novel, hybrid antibiotics and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic prductivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens.

عنوان

Streptomyces in nature and medicine.

شماره استاندارد بين المللي کتاب و موسيقي

9780195150667

موضوع مستند نشده

Streptomyces-- Genetics.

موضوع مستند نشده

Genetic Engineering.

موضوع مستند نشده

Streptomyces-- genetics.

موضوع مستند نشده

SCIENCE-- Life Sciences-- Biology.

موضوع مستند نشده

SCIENCE-- Life Sciences-- Microbiology.

موضوع مستند نشده

MMFM

موضوع مستند نشده

SCI-- 008000

موضوع مستند نشده

SCI-- 045000

شماره

ويراست

شماره رده

نشانه اثر

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

Hopwood, D. A.

تاريخ عمليات

20201204054659.0

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y