عنوان

Advances in cancer research.

شابک

008056254X

شابک

0120066726

شابک

1281409359

شابک

6611409351

شابک

9780080562544

شابک

9780120066728

شابک

9781281409355

شابک

9786611409357

شماره

b725332

عنوان اصلي

Advances in cancer research.

نام عام مواد

[Book]

نام نخستين پديدآور

edited by George F. Vande Woude ; George Klein.

مشخصه جلد

Volume 72 /

محل نشرو پخش و غیره

San Diego :

نام ناشر، پخش کننده و غيره

Academic Press,

تاریخ نشرو بخش و غیره

1998.

نام خاص و کميت اثر

1 online resource (x, 242 pages) :

ساير جزييات

illustrations.

عنوان فروست

Advances in cancer research ;

مشخصه جلد

v. 72

متن يادداشت

Includes bibliographical references and index.

متن يادداشت

Front Cover; Advances in Cancer Research, Volume 72; Copyright Page; Contents; Contributors,Volume 72; Chapter 1. Foulds' Dangerous Idea Revisited: The Multistep Development of Tumors 40 Years Later; I. Foulds' Rules; II. Oncogenetics; III. Other Destabilizing Mutations Caused by Loss of DNA Repair Functions; IV. Molecular Biology of Multistep Carcinogenesis; V. Strong Selective Pressures Favor Multiple Escapes; VI. Conclusion; References; Chapter 2. Cancer Cells Exhibit a Mutator Phenotype; I. Introduction; II. Historical Perspective; III. Requirements for a Mutator Phenotype

متن يادداشت

IV. Modification of B-Myb Protein in the Cell CycleV. The Requirement for B-Myb in Cell Proliferation; VI. B-Myb Function; References; Chapter 5. Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia; I. Introduction; II. Brief History of DNA Methylation in Eukaryotes; III. The Normal Roles for Cytosine Methylation in Higher Order Eukaryotes; IV. Abnormalities of DNA Methylation in Neoplasia; V. Mechanisms Underlying the DNA Methylation Changes in Neoplastic Cells; VI. An Overview of Tumor Progression That Incorporates the Roles of Altered DNA Methylation

متن يادداشت

IV. Origins of MutationsV. Candidate Target Mutator Genes; VI. Microsatellite Instability; VII. Theoretical and Practical Considerations; VIII. Summary and Perspectives; References; Chapter 3. Increasing Complexity of Ras Signal Transduction: Involvement of Rho Family Proteins; I. Introduction; II. Ras is a Point of Convergence for Diverse Extracellular Signal-Stimulated Pathways; III. Ras Activation of Raf-Independent Pathways Contributes to Ras Transformation; IV. Ras Mediates Its Actions through Interaction with Multiple Effectors

متن يادداشت

V. Ras Activation of a GTPase Cascade: An Involvement of Rho Family Proteins in TransformationVI. Rho Family Proteins Mediate Their Actions through Interaction with Multiple Effectors; VII. A Search for the Missing Link between Ras and Rho Family Proteins; VIII. Increasing Complexity of Ras Signal Transduction: A Boon or Bust for Drug Discovery and the Development of Anti-Ras Drugs for Cancer Treatment?; IX. Future Directions; References; Chapter 4. B-Myb: A Key Regulator of the Cell Cycle; I. Introduction; II. B-Myb Structure and Functional Domains; III. Transcriptional Regulation of B-rnyb

متن يادداشت

VII. Clinical Implications of Altered DNA Methylation in CancerReferences; Chapter 6. Ara-C: Cellular and Molecular Pharmacology; I. Introduction; II. Structure; III. Metabolism; IV. Mechanisms of Cytotoxicity; V. Mechanism of Resistance; VI. Signaling Pathways and Oncogene Interactions; VII. Modulation of ara-C Associated Toxicity; VIII. Conclusions; References; Index

بدون عنوان

0

بدون عنوان

8

بدون عنوان

8

بدون عنوان

8

بدون عنوان

8

متن يادداشت

The presentation of Foundations in Cancer Research articles has become a focal point of the Advances in Cancer Research series. This volume begins with two such timely reviews, the first of which is by series co-editor George Klein. Dr. Klein evaluates and reviews Leslie Foulds' suggestion that tumors develop in a series of steps and the effect that this 40-year-old hypothesis has had on cancer research. The second Foundations article by L.A. Loeb presents the historical significance of increased mutagenesis and clonal selection on tumor progression. The first regular article, by R. Khosravi-Far and colleagues, analyzes the functional role of Ras in signal transduction and the involvement that Rho family proteins have on Ras. Mark Saville and Roger Watson review supporting evidence that B-Myb may be a critical regulator of the cell cycle. S. Baylin and co-authors compare DNA methylation in normal cells with that in cancerous cells and discuss the specific consequences associated with tumor progression. Last, Steven Grant discusses the use of ara-C as a treatment for various types of cancer and summarizes its cellular metabolism, mode of action and resistance, and the molecular events involved in apoptosis.

عنوان

Advances in cancer research. Volume 72.

موضوع مستند نشده

Cancer-- Research.

موضوع مستند نشده

Oncology, Experimental.

موضوع مستند نشده

Cancer-- Research.

موضوع مستند نشده

HEALTH & FITNESS-- Diseases-- Cancer.

موضوع مستند نشده

MEDICAL-- Oncology.

موضوع مستند نشده

Oncology, Experimental.

موضوع مستند نشده

HEA-- 039030

موضوع مستند نشده

MED-- 062000

شماره

ويراست

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

Klein, George.

مستند نام اشخاص تاييد نشده

Vande Woude, George F.

تاريخ عمليات

20201213120205.0

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y