عنوان

Antisense drug technology :

شابک

0849387965

شابک

9780849387968

شماره

b714459

عنوان اصلي

Antisense drug technology :

نام عام مواد

[Book]

ساير اطلاعات عنواني

principles, strategies, and applications /

نام نخستين پديدآور

edited by Stanley T. Crooke.

وضعيت ويراست

2nd ed.

محل نشرو پخش و غیره

Boca Raton :

نام ناشر، پخش کننده و غيره

CRC Press,

تاریخ نشرو بخش و غیره

©2008.

نام خاص و کميت اثر

xvii, 825 pages, 12 unnumbered pages of plates :

ساير جزييات

illustrations (some color) ;

ابعاد

27 cm

متن يادداشت

Includes bibliographical references and index.

متن يادداشت

Discovery and development of RNAi therapeutics / Antonin R. deFougerolles and John M. Maraganore -- Optimization of second-generation antisense drugs: going beyond generation 2.0 / Brett P. Monia [and others] -- Modulating gene function with peptide nucleic acids (PNA) / Peter E. Nielsen -- Locked nucleic acid / Troels Koch and Henrik Ørum -- Morpholinos / Patrick L. Iversen -- Potential therapeutic applications of antisense oligonucleotides in ophthalmology / Lisa R. Grillone and Scott P. Henry -- Cardiovascular therapeutic applications / Rosanne M. Crooke, Brenda Baker, and Mark Wedel -- Developing antisense drugs for metabolic diseases: a novel therapeutic approach / Sanjay Bhanot -- Inflammatory diseases / Susan A. Gregory and James G. Karras -- Antisense oligonucleotides for the treatment of cancer / Boris A. Hadaschik and Martin E. Gleave -- Targeting neurological disorders with antisense oligonucleotides / Richard A. Smith and Timothy M. Miller -- Mechanisms and therapeutic applications of immune modulatory oligodeoxynucleotide and oligoribonucleotide ligands for toll-like receptors / Jörg Vollmer and Arthur M. Krieg -- Aptamer opportunities and challenges / Charles Wilson.

متن يادداشت

Mechanisms of antisense drug action, an introduction / Stanley T. Crooke [and others] -- The RNase H mechanism / Walt Lima, Hongjiang Wu, and Stanley T. Crooke -- Small RNA silencing pathways / Alla Sigova and Phillip D. Zamore -- Splice switching oligonucleotides as potential therapeutics / Peter Sazani, Maria A. Graziewicz, and Ryszard Kole -- Basic principles of antisense drug discovery / Susan M. Freier and Andrew T. Watt -- The medicinal chemistry of oligonucleotides / Eric E. Swayze and Balkrishen Bhat -- Basic principles of the pharmacokinetics of antisense oligonucleotide drugs / Arthur A. Levin, Rosie Z. Yu, and Richard S. Geary -- Routes and formulations for delivery of antisense oligonucleotides / Gregory E. Hardee, Lloyd G. Tillman, and Richard S. Geary -- Liposomal formulations for nucleic acid delivery / Ian MacLachlan -- Pharmacological properties of 2'-O-methoxyethyl-modified oligonucleotides / C. Frank Bennett -- Pharmacokinetic/pharmacodynamic properties of phosphorothioate 2'-O-(2-methoxyethyl)-modified antisense oligonucleotides in animals and man / Richard S. Geary [and others] -- Toxicologic properties of 2'-O-methoxyethyl chimeric antisense inhibitors in animals and man / Scott P. Henry [and others] -- An overview of the clinical safety experience of first- and second-generation antisense oligonucleotides / T. Jesse Kwoh -- Manufacturing and analytical processes for 2'-O-(2-methoxyethyl)-modified oligonucleotides / Daniel C. Capaldi and Anthony N. Scozzari -- Utilizing chemistry to harness RNA interference pathways for therapeutics : chemically modified siRNAs and antagomirs / Muthiah Manoharan and Kallanthottathil G. Rajeev.

بدون عنوان

0

بدون عنوان

0

متن يادداشت

This second edition continues to offer answers to challenging questions while looking ahead to the future of antisense drugs, covering the fundamentals of oligonucleotide-based therapeutics and hybridization-based drugs as well as therapeutic applications for cardiovascular purposes, metabolic diseases, and cancer.

موضوع مستند نشده

Antisense nucleic acids-- Therapeutic use.

موضوع مستند نشده

Oligonucleotides, Antisense-- therapeutic use.

موضوع مستند نشده

Acides nucléiques antisens-- Emploi en thérapeutique.

موضوع مستند نشده

Antisense nucleic acids-- Therapeutic use.

موضوع مستند نشده

Antisense-Oligonucleotide

موضوع مستند نشده

Pharmazeutische Technologie

شماره

ويراست

شماره رده

نشانه اثر

شماره رده

شماره رده

شماره رده

نشانه اثر

کد سيستم

مستند نام اشخاص تاييد نشده

Crooke, Stanley T.

تاريخ عمليات

20201208044622.0

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y