Major depressive disorder is one of the most common and debilitating psychiatric disorders. While psychopharmacological treatments exist, they are not universally effective and can produce significant side effects in some patients. The most common psychopharmacological agents used to treat major depression are the selective serotonin reuptake inhibitors, or SSRIs. Often, these drugs take several weeks to relieve depressive symptoms. If the initial therapy fails, other antidepressants are often prescribed. This "trial and error" process creates a delay in remission which can be frustrate the patient and lead to further decreased well-being. Individualized therapy would have great clinical utility by identifying patients that are likely to respond positively to SSRI therapy. The goal of this thesis is to investigate the use of genetic markers for guiding treatment with SSRIs.
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )