Lower urinary tract transitional cell carcinoma in cats:
نام عام مواد
[Article]
نام نخستين پديدآور
Griffin, Maureen A; Culp, William TN; Giuffrida, Michelle A; Ellis, Peter; Tuohy, Joanne; Perry, James A; Gedney, Allison; Lux, Cassie N; Milovancev, Milan; Wallace, Mandy L; Hash, Jonathan; Mathews, Kyle; Liptak, Julius M; Selmic, Laura E; Singh, Ameet; Palm, Carrie A; Balsa, Ingrid M; Mayhew, Philipp D; et al.
عنوان اصلي به قلم نويسنده ديگر
Clinical findings, treatments, and outcomes in 118 cases.
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
BACKGROUND:Lower urinary tract transitional cell carcinoma (TCC) is an important but rarely described disease of cats. OBJECTIVES:To report the clinical characteristics, treatments, and outcomes in a cohort of cats with lower urinary tract TCC and to test identified variables for prognostic relevance. ANIMALS:One-hundred eighteen client-owned cats with lower urinary tract carcinoma. METHODS:Medical records were retrospectively reviewed to obtain information regarding clinical characteristics, treatments, and outcomes. Recorded variables were analyzed statistically. RESULTS:Median age of affected cats was 15 years (range, 5.0-20.8 years) and median duration of clinical signs was 30 days (range, 0-730 days). The trigone was the most common tumor location (32/118; 27.1%) as assessed by ultrasound examination, cystoscopy, or both. Treatment was carried out in 73 of 118 (61.9%) cats. Metastatic disease was documented in 25 of 118 (21.2%) cats. Median progression-free survival and survival time for all cats were 113 days (95% confidence interval [CI], 69-153) and 155 days (95% CI, 110-222), respectively. Survival increased significantly (P < .001) when comparing cats across the ordered treatment groups: no treatment, treatment without partial cystectomy, and treatment with partial cystectomy. Partial cystectomy (hazard ratio [HR], 0.31; 95% CI, 0.17-0.87) and treatment with nonsteroidal anti-inflammatory drugs (HR, 0.55; 95% CI, 0.33-0.93) were significantly associated with longer survival times. CONCLUSIONS AND CLINICAL IMPORTANCE:The results support treatment using partial cystectomy and NSAIDs in cats with TCC.