عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TL5nh1w525
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
Dentate gyrus network reorganization during medial temporal lobe epilepsy leads to dysfunctional dentate neural network in rats
نام عام مواد
[Thesis]
نام نخستين پديدآور
Lam, Vicky
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
UC San Diego
تاریخ نشرو بخش و غیره
2012
یادداشتهای مربوط به پایان نامه ها
کسي که مدرک را اعطا کرده
UC San Diego
امتياز متن
2012
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Theoretical models have suggested that the dentate gyrus (DG) plays a significant role in pattern separation, an important neural-network computation that is critical for memory formation. Patients with medial temporal lobe epilepsy (MTLE), defined by having chronic unprovoked seizures, typically complain of memory impairments. There are many distinct anatomical changes that occur in many MTLE patients, including mossy fiber (mf) sprouting from hippocampal region the DGs granule cells. It is unknown as to whether the observed anatomical reorganization that occurs in the development of MTLE contributes to changes in dentate network function and consequently memory impairments. I therefore proposed to test network functions of the DG in a rat model of MTLE. In this study we looked at the permanent anatomical changes (mf sprouting) of the DG in relation to the functional changes (pattern separation) of the DG network and its downstream target, cornu ammonis region 3 (CA3), in awake-behaving animals. Experiments testing the ability of the dentate network to pattern separate included rats foraging in a series of square and circular environments, while electroencephalograph and extracellular action potentials were recorded. The results showed that the increased amount of pathological reorganization found in the DG (mf sprouting) correlated with the DG cell populations' impaired ability to pattern separate. However, there was no effect on the CA3 region in epileptic rats when compared to control rats
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
Lam, Vicky
شناسه افزوده (تنالگان)
مستند نام تنالگان تاييد نشده
UC San Diego
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
