عنوان

A stochastic multi-scale model of HIV-1 transmission for decision-making:

شماره

LA0d6023qg

عنوان اصلي

A stochastic multi-scale model of HIV-1 transmission for decision-making:

نام عام مواد

[Article]

نام نخستين پديدآور

Yeghiazarian, LilitCumberland, William GYang, Otto O

عنوان اصلي به قلم نويسنده ديگر

application to a MSM population.

متن يادداشت

BACKGROUND:In the absence of an effective vaccine against HIV-1, the scientific community is presented with the challenge of developing alternative methods to curb its spread. Due to the complexity of the disease, however, our ability to predict the impact of various prevention and treatment strategies is limited. While ART has been widely accepted as the gold standard of modern care, its timing is debated. OBJECTIVES:To evaluate the impact of medical interventions at the level of individuals on the spread of infection across the whole population. Specifically, we investigate the impact of ART initiation timing on HIV-1 spread in an MSM (Men who have Sex with Men) population. DESIGN AND METHODS:A stochastic multi-scale model of HIV-1 transmission that integrates within a single framework the in-host cellular dynamics and their outcomes, patient health states, and sexual contact networks. The model captures disease state and progression within individuals, and allows for simulation of therapeutic strategies. RESULTS:Early ART initiation may substantially affect disease spread through a population. CONCLUSIONS:Our model provides a multi-scale, systems-based approach to evaluate the broader implications of therapeutic strategies.

تاريخ نشر

2013

عنوان

UCLA

نام الکترونيکي

نوع ماده

[Article]

کد کاربرگه

278612

سطح دسترسي

a

تكميل شده

Y