عنوان

Emerging treatment options for the management of brain metastases in patients with HER2-positive metastatic breast cancer.

شماره

LA6z05n6r1

عنوان اصلي

Emerging treatment options for the management of brain metastases in patients with HER2-positive metastatic breast cancer.

نام عام مواد

[Article]

نام نخستين پديدآور

Chien, A JoRugo, Hope S

متن يادداشت

The widespread use of trastuzumab in the past decade has led to a significant and measureable improvement in the survival of patients with human epidermal growth factor receptor-2 (HER2) overexpressing breast cancer, and in many ways has redefined the natural history of this aggressive breast cancer subtype. Historically, survival in patients with HER2-positive disease was dictated by the systemic disease course, and what appears to be the central nervous system (CNS) tropism associated with HER2-amplified tumors was not clinically evident. With improved systemic control and prolonged survival, the incidence of brain metastases has increased, and CNS disease, often in the setting of well-controlled extracranial disease, is proving to be an increasingly important and clinically challenging cause of morbidity and mortality in patients with HER2-positive advanced breast cancer. This review summarizes the known clinical data for the systemic treatment of HER2-positive CNS metastases and includes information about ongoing clinical trials of novel therapies as well as emerging strategies for early detection and prevention.

تاريخ نشر

2013

عنوان

UCSF

نام الکترونيکي

نوع ماده

[Article]

کد کاربرگه

278578

سطح دسترسي

a

تكميل شده

Y