عنوان

Eggs early in complementary feeding increase choline pathway biomarkers and DHA:

شماره

LA8xr9j9n5

عنوان اصلي

Eggs early in complementary feeding increase choline pathway biomarkers and DHA:

نام عام مواد

[Article]

نام نخستين پديدآور

Iannotti, Lora LLutter, Chessa KWaters, William FGallegos Riofrío, Carlos AndresMalo, CarlaReinhart, GregoryPalacios, AnaKarp, CeliaChapnick, MelissaCox, KatherineAguirre, SantiagoNarvaez, LuisLópez, FernandoSidhu, RohiniKell, PamelaJiang, XuntianFujiwara, HidejiOry, Daniel Set al.

عنوان اصلي به قلم نويسنده ديگر

a randomized controlled trial in Ecuador.

متن يادداشت

Background: Choline status has been associated with stunting among young children. Findings from this study showed that an egg intervention improved linear growth by a length-for-age z score of 0.63.Objective: We aimed to test the efficacy of eggs introduced early in complementary feeding on plasma concentrations of biomarkers in choline pathways, vitamins B-12 and A, and essential fatty acids.Design: A randomized controlled trial, the Lulun ("egg" in Kichwa) Project, was conducted in a rural indigenous population of Ecuador. Infants aged 6-9 mo were randomly assigned to treatment (1 egg/d for 6 mo; n = 80) and control (no intervention; n = 83) groups. Socioeconomic data, anthropometric measures, and blood samples were collected at baseline and endline. Household visits were made weekly for morbidity surveillance. We tested vitamin B-12 plasma concentrations by using chemiluminescent competitive immunoassay and plasma concentrations of choline, betaine, dimethylglycine, retinol, essential fatty acids, methionine, dimethylamine (DMA), trimethylamine, and trimethylamine-N-oxide (TMAO) with the use of liquid chromatography-tandem mass spectrometry.Results: Socioeconomic factors and biomarker concentrations were comparable at baseline. Of infants, 11.4% were vitamin B-12 deficient and 31.7% marginally deficient at baseline. In adjusted generalized linear regression modeling, the egg intervention increased plasma concentrations compared with control by the following effect sizes: choline, 0.35 (95% CI: 0.12, 0.57); betaine, 0.29 (95% CI: 0.01, 0.58); methionine, 0.31 (95% CI: 0.03, 0.60); docosahexaenoic acid, 0.43 (95% CI: 0.13, 0.73); DMA, 0.37 (95% CI: 0.37, 0.69); and TMAO, 0.33 (95% CI: 0.08, 0.58). No significant group differences were found for vitamin B-12, retinol, linoleic acid (LA), α-linolenic acid (ALA), or ratios of betaine to choline and LA to ALA.Conclusion: The findings supported our hypothesis that early introduction of eggs significantly improved choline and other markers in its methyl group metabolism pathway. This trial was registered at clinicaltrials.gov as NCT02446873.

تاريخ نشر

2017

عنوان

UC Davis

نام الکترونيکي

نوع ماده

[Article]

کد کاربرگه

277605

سطح دسترسي

a

تكميل شده

Y