Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography.
نام عام مواد
[Article]
نام نخستين پديدآور
Eberle, Melissa MHsu, Mike SRodriguez, Carissa LSzu, Jenny IOliveira, Michael CBinder, Devin KPark, B Hyle
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متن يادداشت
Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth-resolved cross-sectional images. In this study, OCT was used to detect changes in the optical properties of cortical tissue in vivo in mice during the induction of global (pentylenetetrazol) and focal (4-aminopyridine) seizures. Through the use of a confidence interval statistical method on depth-resolved volumes of attenuation coefficient, we demonstrated localization of regions exhibiting both significant positive and negative changes in attenuation coefficient, as well as differentiating between global and focal seizure propagation.