عنوان

In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography.

شماره

LA0p28n6tg

عنوان اصلي

In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography.

نام عام مواد

[Article]

نام نخستين پديدآور

Eberle, Melissa MReynolds, Carissa LSzu, Jenny IWang, YanHansen, Anne MHsu, Mike SIslam, M ShahidulBinder, Devin KPark, B Hyle

متن يادداشت

The most common technology for seizure detection is with electroencephalography (EEG), which has low spatial resolution and minimal depth discrimination. Optical techniques using near-infrared (NIR) light have been used to improve upon EEG technology and previous research has suggested that optical changes, specifically changes in near-infrared optical scattering, may precede EEG seizure onset in in vivo models. Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth resolved cross-sectional images. In this study, OCT was used to detect changes in optical properties of cortical tissue in vivo in mice before and during the induction of generalized seizure activity. We demonstrated that a significant decrease (P < 0.001) in backscattered intensity during seizure progression can be detected before the onset of observable manifestations of generalized (stage-5) seizures. These results indicate the feasibility of minimally-invasive optical detection of seizures with OCT.

تاريخ نشر

2012

عنوان

UC Riverside

نام الکترونيکي

نوع ماده

[Article]

کد کاربرگه

275786

سطح دسترسي

a

تكميل شده

Y