عنوان

Progranulin and central nervous system disorders /

شابک

9789811361869

شابک

9789811361876

شابک

9789811361883

شابک

981136186X

شابک

9811361878

شابک

9811361886

شابک اشتباه

9789811361852

شابک اشتباه

9811361851

عنوان اصلي

Progranulin and central nervous system disorders /

نام عام مواد

[Book]

نام نخستين پديدآور

Hideaki Hara [and 4 others], editors.

محل نشرو پخش و غیره

Singapore :

نام ناشر، پخش کننده و غيره

Springer,

تاریخ نشرو بخش و غیره

2019.

نام خاص و کميت اثر

1 online resource

متن يادداشت

Molecular and functional properties of progranulin -- Progranulin as a potential biomarker of central nervous system disease -- Progranulin and frontotemporal lobar degeneration -- PGRN and neurodegenerative dieseases other than FTLD -- Progranulin regulations of lysosomal homeostatis and its involvement in neurodegenerative diseases -- Progranulin in sexual differentiation of the developing brain -- Progranulin and inflammation/neuroinflammation -- Neural stem/progenitor cells and progranulin -- Generationa nd phenotyping of progranulin-deficient mice -- Pleiotropic protective effects of progranulin in the treatment of ischemic stroke -- New therapeutic appraoches against ocular diseases.

بدون عنوان

0

متن يادداشت

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.

منبع سفارش / آدرس اشتراک

Springer Nature

شماره انبار

com.springer.onix.9789811361869

عنوان

Progranulin and central nervous system disorders.

شماره استاندارد بين المللي کتاب و موسيقي

9789811361852

موضوع مستند نشده

Glycoproteins.

موضوع مستند نشده

Neurogenetics.

موضوع مستند نشده

Proteins.

موضوع مستند نشده

Glycoproteins.

موضوع مستند نشده

Neurogenetics.

موضوع مستند نشده

Proteins.

موضوع مستند نشده

SCIENCE-- Life Sciences-- Biochemistry.

موضوع مستند نشده

MFN

موضوع مستند نشده

MFN

موضوع مستند نشده

SCI-- 007000

شماره

ويراست

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

Hara, Hideaki

مستند نام اشخاص تاييد نشده

Hosokawa, Masato.

مستند نام اشخاص تاييد نشده

Nakamura, Shinsuke.

مستند نام اشخاص تاييد نشده

Nishihara, Masugi.

مستند نام اشخاص تاييد نشده

Shimohata, Takayoshi.

تاريخ عمليات

20200823233524.0

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y