عنوان

Molecular recognition of DNA double helix :

شابک

9789811087462

شابک

9811087466

شابک اشتباه

9789811087455

عنوان اصلي

Molecular recognition of DNA double helix :

نام عام مواد

[Book]

ساير اطلاعات عنواني

gene regulation and photochemistry of BrU substituted DNA ; development of chemical biology tools /

نام نخستين پديدآور

Abhijit Saha.

محل نشرو پخش و غیره

Singapore :

نام ناشر، پخش کننده و غيره

Springer,

تاریخ نشرو بخش و غیره

2018.

نام خاص و کميت اثر

1 online resource (xvi, 114 pages) :

ساير جزييات

illustrations (some color)

عنوان فروست

Springer theses,

شاپا ي ISSN فروست

2190-5053

متن يادداشت

"Doctoral thesis accepted by Kyoto University, Kyoto, Japan."

متن يادداشت

Includes bibliographical references.

متن يادداشت

1. Overview of DNA minor groove binding synthetic small molecules and photochemistry of BrU substituted DNA -- 2. Synthesis and Biological Evaluation of Targeted Transcriptional Activator with HDAC8 Inhibitory Activity -- 3. Chemical Modification of a Synthetic Small Molecule Boosts its Biological Efficacy against Pluripotency Genes in Mouse Fibroblast -- 4. Development of a novel photochemical detection technique for the analysis of polyamide binding sites -- 5. Examining cooperative binding of Sox2 on DC5 regulatory element upon complex formation with Pax6 through excess electron transfer assay -- 6. UVA irradiation of BrU-substituted DNA in the presence of Hoechst 33258.

بدون عنوان

0

متن يادداشت

In this book, the molecular recognition of DNA using small molecules is discussed, with a study of the photochemistry of BrU-labeled DNA. The purposes of the study were to develop small molecules for regenerative medicine, to develop a method to detect the recognition site of small molecules, and to detect the most important biological phenomena using the photochemistry of BrU-labeled DNA. The study began with the design and development of small molecules that can induce pluripotency genes. To deal with the important issue of cell permeability of the original compound, a new analogue of the original with improved gene expression was designed and synthesized. Using the photochemistry of BrU-labeled DNA, crucial biological phenomena such as cooperativity between transcription factors were detected. For the first time, the cooperativity was examined by excess electron transfer assay. DNA was also studied very carefully in order to understand the mechanism of the double-strand break in the UVA micro-irradiation technique. The mechanism of the double strand remained untouched. Nevertheless, the double-strand break mechanism was clearly demonstrated by Hoechst dye, as shown in this book.

منبع سفارش / آدرس اشتراک

Springer Nature

شماره انبار

com.springer.onix.9789811087462

موضوع مستند نشده

DNA.

موضوع مستند نشده

Molecular recognition.

موضوع مستند نشده

DNA.

موضوع مستند نشده

Molecular recognition.

موضوع مستند نشده

SCIENCE-- Life Sciences-- Biochemistry.

موضوع مستند نشده

SCI-- 007000

شماره

ويراست

شماره رده

مستند نام اشخاص تاييد نشده

Saha, Abhijit

تاريخ عمليات

20200823222945.0

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y