عنوان

Precision molecular pathology of neoplastic pediatric diseases /

شابک

3030078183

شابک

3319896261

شابک

331989627X

شابک

9783030078188

شابک

9783319896267

شابک

9783319896274

شابک اشتباه

3319896253

شابک اشتباه

9783319896250

عنوان اصلي

Precision molecular pathology of neoplastic pediatric diseases /

نام عام مواد

[Book]

نام نخستين پديدآور

Larissa V. Furtado, Aliya N. Husain, editors.

محل نشرو پخش و غیره

Cham, Switzerland :

نام ناشر، پخش کننده و غيره

Springer,

تاریخ نشرو بخش و غیره

2018.

نام خاص و کميت اثر

1 online resource

عنوان فروست

Molecular pathology library,

شاپا ي ISSN فروست

1935-987X

متن يادداشت

Includes index.

متن يادداشت

Intro; Contents; Contributors; Part I: Molecular Pathology of Pediatric Neoplasms: General Principles; Chapter 1: Principles of Molecular Biology and Oncogenesis; Principles of Molecular Biology; Nucleic Acid Structure, Composition, and Organization; Gene Structure, Organization, and Expression; Chromosome Structure; Mitochondrial DNA; Principles of Oncogenesis; Oncogenes; Tumor Suppressor Genes; References; Chapter 2: Molecular Methods in Oncology: Targeted Mutational Analysis; PCR-Based Techniques; Overview; Background; Method; Template; Primers; Polymerase; Procedure.

متن يادداشت

Advantages/DisadvantagesAdvantages; Disadvantages; Applications; Variations; Reverse Transcriptase PCR (RT-PCR); Real-Time PCR/Quantitative PCR (qPCR); Nested PCR; Multiplex PCR; Allele-Specific PCR (ASPCR); Digital PCR (dPCR); Methylation-Specific PCR; Fluorescence In Situ Hybridization (FISH); Overview; Background; Method; Probes; Targets; Procedure; Signals and Detection; Advantages and Disadvantages; Advantages; Disadvantages; Applications; Chromosomal Aneusomies; Segmental Deletions; Single Gene Amplification; Translocations; Other Clinically Relevant FISH Variants; References.

متن يادداشت

Chapter 3: Molecular Methods in Oncology: Genomic AnalysisNext-Generation Sequencing; Overview; Background; Methods; Next-Generation Sequencing (NGS); Solexa/Illumina; Ion Semiconductor Sequencing; Single-Molecule Real-Time (SMRT) Sequencing; Sequencing by Oligonucleotide Ligation and Detection (SOLiD); Data Analysis; Applications; Chromosomal Microarray; Overview; Background; Methods; General Principles; Comparative Genomic Hybridization (CGH); DNA Sequence Analysis; Gene Expression Profiling; Advantages and Disadvantages; Applications; References.

متن يادداشت

Chapter 4: Molecular Testing in Pediatric Oncology PracticeIntroduction; Indications for Molecular Testing; Diagnosis; Prognosis; Therapeutic Guidance; Disease Status Monitoring; Inherited Susceptibility; Specimens for Molecular Testing; Peripheral Blood; Bone Marrow; Tissue; Cytology Specimens; Acellular Body Fluids; Buccal Swab/Saliva; Skin/Fibroblast Culture; Specimen Collection/Handling Procedures; Selecting the Appropriate Molecular Test; What Is the Test Purpose?; What Are the Possible Specimen Options?; What Are the Available Test Options?

متن يادداشت

How Does the Clinical Scenario Impact the Decision?Interpretation and Integration of Test Results; Ethical Considerations in Pediatric Genomic Oncology Testing; References; Chapter 5: Molecular Targeted Therapy of Pediatric Neoplasms; Introduction; Mechanisms to Identify Potential Targets; Mechanisms to Target Cancer Cells; Metabolic Differences; Asparaginase; Methotrexate; DFMO; Aberrant Signaling; Tyrosine Kinase Inhibitors; Imatinib, Dasatinib; Ruxolitinib; Pazopanib; WEE1 Inhibitor; Serine/Threonine Kinase Inhibitors; Everolimus; Temsirolimus; Targeting Restricted Protein Expression.

بدون عنوان

0

بدون عنوان

8

بدون عنوان

8

بدون عنوان

8

بدون عنوان

8

متن يادداشت

This book provides a comprehensive, state-of-the art review of pediatric oncology. The text covers relevant concepts in molecular biology and addresses technical principles, applications, challenges, and integration of current and emerging genomic and molecular methods in the diagnosis and personalized management of childhood cancers. The text also discusses a wide array of pediatric neoplasms in the context of molecular pathology in a concise and understandable manner, with focus on their molecular pathogenesis, clinicopathological features, classification, molecular diagnosis, and approaches to personalized care. Written by experts in the field, Precision Molecular Pathology of Neoplastic Pediatric Diseases serves as a valuable resource for pathologists, pediatric oncologists, trainees and researchers with an interest in pediatric and molecular pathology.

منبع سفارش / آدرس اشتراک

Springer Nature

شماره انبار

com.springer.onix.9783319896267

عنوان

Precision molecular pathology of neoplastic pediatric diseases.

شماره استاندارد بين المللي کتاب و موسيقي

9783319896250

موضوع مستند نشده

Tumors in children-- Molecular aspects.

موضوع مستند نشده

HEALTH & FITNESS-- Diseases-- General.

موضوع مستند نشده

MEDICAL-- Clinical Medicine.

موضوع مستند نشده

MEDICAL-- Diseases.

موضوع مستند نشده

MEDICAL-- Evidence-Based Medicine.

موضوع مستند نشده

MEDICAL-- Internal Medicine.

موضوع مستند نشده

Medicine.

موضوع مستند نشده

Oncology.

موضوع مستند نشده

Oncology.

موضوع مستند نشده

Pathology.

موضوع مستند نشده

Pathology.

موضوع مستند نشده

HEA-- 039000

موضوع مستند نشده

MED-- 014000

موضوع مستند نشده

MED-- 022000

موضوع مستند نشده

MED-- 045000

موضوع مستند نشده

MED-- 112000

موضوع مستند نشده

MKF

موضوع مستند نشده

MMF

شماره

ويراست

شماره رده

مستند نام اشخاص تاييد نشده

Furtado, Larissa V.

مستند نام اشخاص تاييد نشده

Husain, Aliya N.

تاريخ عمليات

20200823114611.0

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y