عنوان

HIV-1 latency /

شابک

303002816X

شابک

3030028178

شابک

9783030028169

شابک

9783030028176

شابک اشتباه

3030028151

شابک اشتباه

9783030028152

عنوان اصلي

HIV-1 latency /

نام عام مواد

[Book]

نام نخستين پديدآور

Guido Silvestri, Mathias Lichterfeld, editors.

محل نشرو پخش و غیره

Cham, Switzerland :

نام ناشر، پخش کننده و غيره

Springer,

تاریخ نشرو بخش و غیره

[2018]

نام خاص و کميت اثر

1 online resource

عنوان فروست

Current topics in microbiology and immunology,

مشخصه جلد

volume 417

شاپا ي ISSN فروست

0070-217X ;

متن يادداشت

Intro; Preface; Contents; 74 Molecular Control of HIV and SIV Latency; Abstract; 1 Introduction; 2 The HIV-1 and SIVmac Promoters; 3 Regulation of HIV-1/SIV Transcription; 3.1 Nuclear Topography; 3.2 Viral Integration Site; 3.3 Epigenetic Modifications of HIV-1/SIV Promoter; 3.4 Regulation of HIV-1 Transcription by Tat/P-TEFb; 3.5 The Role of Cellular Transcription Factors; 4 Post-transcriptional Regulation of HIV-1 Expression; 4.1 HIV-1 mRNA Processing and Latency; 4.2 Noncoding mRNAs and HIV-1 Latency; 5 Concluding Remarks; References

متن يادداشت

5.1 Antiretroviral Drugs That Have Been Utilized in NHPs5.2 Future cART Regimen Development for NHPs; 6 Alternative Models; 6.1 Chinese-Origin Rhesus Macaques; 6.2 RT-SHIV Infections; 6.3 SIVagm.sab Infections; 6.4 CNS Infection Models; 6.5 Envelope SHIVs; 7 Virologic Assays; 7.1 PCR and RT-PCR-Based Assays; 7.2 In Situ Approaches; 7.3 Other Virologic Assessments; 8 Concluding Remarks; Financial Support; References; 89 SIV Latency in Macrophages in the CNS; Abstract; 1 Introduction; 2 HIV Infection and SIV Infection in the CNS; 3 New Insights on Macrophage Origin and Phenotypes

متن يادداشت

73 Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral TherapyAbstract; 1 Introduction; 2 NHP/AIDS Models; 2.1 HIV-1 Infection of Nonhuman Primates; 2.2 Discovery of Simian Immunodeficiency Virus (SIV) and Simian AIDS; 2.3 SIV Infection in Different NHP Species; 3 Advantages of NHP Models for HIV/AIDS Cure Research; 4 Challenges for Using NHP/AIDS Models for HIV Cure Research; 4.1 Logistical Challenges; 4.2 Challenges in cART Administration to AIDS Virus Infected NHP; 5 Administration of Antiretroviral Drugs to NHPs

متن يادداشت

75 Assays to Measure Latency, Reservoirs, and ReactivationAbstract; 1 Introduction; 2 Definitions; 3 The Viral Outgrowth Assay; 3.1 Assay Design and Rationale; 3.2 Recent Improvements and Potential Problems with the QVOA; 4 The Proviral Landscape: Defective and Non-induced Proviruses; 5 Other Reservoir Assays; 5.1 PCR and Hybridization-Based Assays; 5.2 Induction Assays; 6 Other Approaches to Reservoir Measurement; 6.1 Residual Viremia; 6.2 Biomarkers; 6.3 Time to Rebound; 7 Conclusions; Acknowledgements; References; 72 The Antiviral Immune Response and Its Impact on the HIV-1 Reservoir

متن يادداشت

Abstract1 Introduction; 2 Innate Immune Response; 2.1 Type I Interferon and Restriction Factors; 2.2 Natural Killer Cells; 3 Adaptive Immune Response: Humoral Immunity; 3.1 HIV-1-Specific Antibodies; 3.2 The Development of Broadly Neutralizing Abs; 3.3 Abs as a Preventative or Therapeutic Treatment; 3.4 Bispecific Abs; 4 Adaptive Immune Response: Cellular Immunity; 4.1 HIV-1-Specific CD8+T Cells; 4.2 CD8+T Cell Responses in Patients with Natural Control of HIV-1 Infection; 4.3 CD8+T Cell Based Vaccines; 4.4 CD8+T Cell Based "Shock and Kill" Therapy; 5 Conclusions; References

بدون عنوان

0

بدون عنوان

8

بدون عنوان

8

بدون عنوان

8

بدون عنوان

8

متن يادداشت

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.

منبع سفارش / آدرس اشتراک

Springer Nature

شماره انبار

com.springer.onix.9783030028169

عنوان

HIV-1 latency.

شماره استاندارد بين المللي کتاب و موسيقي

9783030028152

موضوع مستند نشده

HIV (Viruses)

موضوع مستند نشده

HIV infections.

موضوع مستند نشده

Epidemiology & medical statistics.

موضوع مستند نشده

HEALTH & FITNESS-- Diseases-- General.

موضوع مستند نشده

HIV (Viruses)

موضوع مستند نشده

HIV infections.

موضوع مستند نشده

Immunology.

موضوع مستند نشده

MEDICAL-- Clinical Medicine.

موضوع مستند نشده

MEDICAL-- Diseases.

موضوع مستند نشده

MEDICAL-- Evidence-Based Medicine.

موضوع مستند نشده

MEDICAL-- Internal Medicine.

موضوع مستند نشده

Medical microbiology & virology.

موضوع مستند نشده

Pathology.

موضوع مستند نشده

HEA-- 039000

موضوع مستند نشده

MED-- 014000

موضوع مستند نشده

MED-- 022000

موضوع مستند نشده

MED-- 045000

موضوع مستند نشده

MED-- 112000

موضوع مستند نشده

MJCM

موضوع مستند نشده

MJCM

شماره

ويراست

شماره رده

مستند نام اشخاص تاييد نشده

Lichterfeld, Mathias

مستند نام اشخاص تاييد نشده

Silvestri, Guido, (Professor of pathology and laboratory medicine)

تاريخ عمليات

20200823074639.0

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y