عنوان

Short term physiological changes secondary to exercise in intermittent claudication :

شماره

TLets631125

عنوان اصلي

Short term physiological changes secondary to exercise in intermittent claudication :

نام عام مواد

[Thesis]

نام نخستين پديدآور

Gohil, Risha

عنوان اصلي به قلم نويسنده ديگر

short term physiological changes in claudication

نام ناشر، پخش کننده و غيره

University of Hull and the University of York

تاریخ نشرو بخش و غیره

2013

جزئيات پايان نامه و نوع درجه آن

Thesis (M.D.)

امتياز متن

2013

متن يادداشت

Background: In patients with intermittent claudication (IC), supervised exercise programmes (SEP) improve walking distance and quality of life (QoL); however the mechanisms by which these benefits are achieved remain unclear. Endothelial dysfunction is recognised as a trigger of the atheroinflammatory cascade and subsequent cardiovascular disease. In health, training improves cardiorespiratory physiology, inflammation and endothelial function. Changes in cardiorespiratory physiology, inflammatory markers and endothelial function are contradictory in IC. Objectives: This thesis aimed to assess the impact of SEP on cardiopulmonary physiology, endothelial function and athero-inflammatory markers in patients with IC. Methods: Following local research ethics committee and R & D approval, patients with IC were recruited from outpatient clinic. After providing informed written consent, patients underwent baseline assessment on two separate days. Session 1: participants completed a constant load treadmill test with pre and post exercise ankle brachial pressure indices. Session 2: measured QoL, endothelial function (EndoPAT2000, Itamar, Israel), venepuncture and a cardiopulmonary exercise test (CPET) using cycle ergometry. Participants then underwent a 12 week period of SEP which consisted of circuit training, with re-assessments at six and twelve weeks. The primary outcome measure was a 1.5ml/kg/min improvement in peak VO₂ after six weeks of exercise. Secondary outcomes included changes in endothelial function, quality of life, walking distance and inflammatory markers at both six and twelve weeks. Results: No significant improvements in CPET measurements, endothelial function or inflammation were demonstrated at any time point. Traditional markers of walking ability and QoL demonstrated an improvement by 12 weeks. Conclusions: The underlying mechanism through which exercise improves walking distance remains un-identified. Further work regarding the changes at the cellular level within the muscle is of importance.

موضوع مستند نشده

Medicine

مستند نام اشخاص تاييد نشده

Gohil, Risha

مستند نام تنالگان تاييد نشده

University of Hull

نام الکترونيکي

فرمت انتشار

p

نوع ماده

[Thesis]

کد کاربرگه

276903

سطح دسترسي

a

تكميل شده

Y