عنوان

Brain diseases and metalloproteins

شابک

9789814316019

شابک

9789814364072

شابک

9814316016

شابک

981436407X

شماره

b597260

عنوان اصلي

Brain diseases and metalloproteins

نام عام مواد

[Book]

نام نخستين پديدآور

edited by David R. Brown.

محل نشرو پخش و غیره

Singapore

نام ناشر، پخش کننده و غيره

Pan Stanford Pub

تاریخ نشرو بخش و غیره

2013

متن يادداشت

Introduction David R. BrownBrain DiseasesMetalloproteinsA Possible Key Role for Redox-Active Metal Ions and Soluble Oligomers in Neurodegenerative Disease Brian J. Tabner, Susan Moore, Jennifer Mayes, and David AllsopSummaryIntroduction to the ProteopathiesMutations in Genes Associated with Protein Processing and Aggregation Cause Inherited Forms of ProteopathyThe Toxic Eff ects of Protein Oligomers The Generation of Hydrogen Peroxide by Ass Other Aggregating Protein Systems Mechanism of Hydrogen Peroxide Formation and Ass Oxidation Concluding Comments Modelling of the Metal Binding Sites in Proteins Involved in Neurodegeneration Ewa Gralka, Daniela Valensin, Maurizio Remelli, and Henryk KozlowskiIntroductionPeptides as Models for Unstructured Protein Interactions with Metal IonsStructural Approach to Metal-Peptide Interactions (Role of His as the Metal Ion Binding Site)Thermodynamic and Speciation StudiesImpact of Metal Ions on Prion Protein Fibril FormationImpact of Metal-Peptide Interaction on Oxidative StressMammalian Metallothioneins Duncan E. K. Sutherland and Martin J. StillmanMetallothioneinTechniques for Studying MetallothioneinsMT-1 and MT-2: Inducible MetallothioneinsMT-3: A Central Nervous System MetallothioneinCopper Transporting P-Type ATPases in the Brain Sharon La Fontaine, James Camakaris, and Julian MercerATP7A in the BrainATP7B in the BrainConclusionRole of the Amyloid Precursor Protein and Copper in Alzheimer's Disease Loredana Spoerri, Kevin J. Barnham, Gerd Multhaup and Roberto CappaiThe Amyloid Precursor ProteinCopper PhysiologyCopper and Alzheimer's DiseaseAPP, Copper and Alzheimer's DiseaseAPP Copper Binding Domain (CuBD)ConclusionsRole of Aluminum and Other Metal Ions in the Pathogenesis of Alzheimer's Disease Silvia Bolognin and Paolo ZattaAlzheimer's Disease The Amyloid Cascade and Oligomer Hypothesis Metal Dysmetabolism in AD The Role of Metal Ions in the Aggregation and Toxicity of Ass Ass and Cell Membranes Amyloid Metal Complexes and Ca ConclusionPrion Diseases, Metals and Antioxidants Paul Davies and David R. BrownThe Transmissible Spongiform EncephalopathiesThe Prion ProteinPrP and Copper Binding The Implications of Copper Binding Other MetalsMetals and Aggregation Changes in Brain Metals PrP Survival in the Environment Conclusion Emerging Role for Copper-Bound -Synuclein in Parkinson's Disease Etiology Heather R. Lucas and Jennifer C. LeeIntroductionInteraction of Copper(II) and -Synuclein Metal-Catalysed Protein Oxidation ConclusionInteractions of -Synuclein with Metal Ions: New Insights into the Structural Biology and Bioinorganic Chemistry of Parkinson's Disease Andres Binolfi and Claudio O. FernandezIntroductionInteraction of AS with Cu(II) IonsInteraction of AS with Other Divalent Metal IonsStructural Details Behind the Specificity of AS-Cu(II) InteractionsConclusions and Future Perspectives An Attempt to Treat Amyotrophic Lateral Sclerosis by Intracellular Copper Modification Using Ammonium Tetrathiomolybdate and/or Metallothionein: Fundamentals and Perspective 367 Shin-Ichi Ono, Ei-Ichi Tokuda, Eriko Okawa, and Shunsuke WatanabeIntroductionCauses of ALSCharacterization of G93A Mutant SOD1 MouseMetallothionein, Copper Ions and ALSCellular Damage by Copper OverloadTherapeutic Strategy in Mutant SOD1 Mice Based on "Intracellular Cu Dysregulation" Hypothesis: Intracellular Copper Removal Using Ammonium TetrathiomolybdateTherapeutic Strategy in Mutant SOD1 Mice Based on "Intracellular Cu Dysregulation" Hypothesis: Intracellular Copper Modification Using a Metallothionein-I IsoformConclusionIndex

موضوع مستند نشده

Brain -- Diseases.

موضوع مستند نشده

Metalloproteins.

موضوع مستند نشده

Metallproteide

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

edited by David R. Brown.

مستند نام اشخاص تاييد نشده

David R Brown

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y