عنوان

Molecular and Cell Biology of Muscular Dystrophy

شابک

9401046670

شابک

9401115281

شابک

9789401046671

شابک

9789401115285

شماره

b594861

عنوان اصلي

Molecular and Cell Biology of Muscular Dystrophy

نام عام مواد

[Book]

نام نخستين پديدآور

edited by Terence Partridge.

محل نشرو پخش و غیره

Dordrecht

نام ناشر، پخش کننده و غيره

Springer Netherlands

تاریخ نشرو بخش و غیره

1993

نام خاص و کميت اثر

(xvi, 344 pages)

عنوان فروست

Molecular and cell biology of human diseases series.

متن يادداشت

1 Molecular human genetics and the Duchenne/Becker muscular dystrophy gene --; 1.1 Introduction --; 1.2 DMD and BMD phenotype --; 1.3 Localization to Xp21 --; 1.4 Isolation of Xp21 sequences --; 1.5 Chromosome walking and jumping in Xp21 --; 1.6 Identification of expressed sequences --; 1.7 Gene sequence and organization --; 1.8 Genotype and phenotype --; 1.9 Dystrophin --; 1.10 Conclusions --; References --; 2 Genotype/phenotype correlations in Duchenne/Becker dystrophy --; 2.1 Introduction --; 2.2 Duchenne muscular dystrophy --; 2.3 Dystrophinopathy in girls and women --; 2.4 Becker muscular dystrophy --; 2.5 Conclusion --; References --; 3 Molecular genetics and genetic counselling for Duchenne/Becker muscular dystrophy --; 3.1 Introduction --; 3.2 Duchenne and Becker muscular dystrophy --; 3.3 Genetic counselling for Duchenne and Becker muscular dystrophy: prior to molecular genetics --; 3.4 Genetic counselling of Duchenne and Becker muscular dystrophy post molecular genetics --; 3.5 Genetic counselling of Duchenne and Becker muscular dystrophy: Future --; 3.6 Conclusion --; Acknowledgements --; References --; 4 Inheritance and pathogenicity of myotonic dystrophy --; 4.1 Introduction --; 4.2 The clinical picture --; 4.3 Biochemical, electrophysiological and histological findings --; 4.4 Genetic mapping of the myotonic locus --; 4.5 Physical mapping --; 4.6 Isolation of the DM region as a series of overlapping genomic clones --; 4.7 Identifying candidate genes --; 4.8 Future prospects --; Acknowledgements --; References --; 5 Genetic mapping of facioscapulohumeral muscular dystrophy --; 5.1 Introduction --; 5.2 Positional cloning --; 5.3 Facioscapulohumeral muscular dystrophy: clinical features --; 5.4 FSHD: Linkage analysis and positional cloning --; Acknowledgements --; References --; 6 Dystrophin-associated glycoproteins: their possible roles in the pathogenesis of Duchenne muscular dystrophy --; 6.1 Introduction --; 6.2 Membrane properties of dystrophin --; 6.3 Dystrophin --; glycoprotein complex --; 6.4 Structure and function of dystroglycan (43/156 dystrophin-associated glycoprotein) --; 6.5 Molecular pathogenesis of Duchenne muscular dystrophy --; 6.6 Summary --; Acknowledgements --; References --; 7 PCR analysis of muscular dystrophy in mdx mice --; 7.1 Introduction --; 7.2 Mouse dystrophin cDNA clones --; 7.3 mdx mice --; 7.4 PCR analysis of mouse dystrophin expression --; 7.5 Summary --; Acknowledgements --; References --; 8 Cell biology of the satellite cell --; 8.1 Introduction --; 8.2 Satellite cells in normal muscle --; 8.3 Behaviour of satellite cells in damaged muscle --; 8.4 Satellite cells, myoblasts and implant therapy --; References --; 9 Molecular and cell biology of skeletal muscle regeneration --; 9.1 Introduction --; 9.2 Developmental origin of satellite cells and their identification in vivo --; 9.3 Replication during postnatal growth --; 9.4 Numbers and proliferative capacity of mpc from animals of different ages --; 9.5 The influence of growth factors and extracellular matrix components on the proliferation and differentiation of mpc --; Acknowledgements --; References --; 10 Molecular mechanisms of muscle damage --; 10.1 Introduction --; 10.2 The mechanisms of damage to normal skeletal muscle subjected to various damaging stresses --; 10.3 Mechanisms of damage in dystrophin-deficient muscle --; 10.4 Conclusions --; Acknowledgements --; References --; 11 Human dystrophin gene transfer: Genetic correction of dystrophin deficiency --; 11.1 Somatic gene therapy: An introduction --; 11.2 Therapeutic targets in Duchenne muscular dystrophy --; 11.3 Recombinant dystrophin genes: Their nature and availability --; 11.4 Physical gene transfer techniques --; 11.5 Viral-mediated gene transfer strategies --; 11.6 Studies in transgenic animals: Germ line gene transfer --; 11.7 Dystrophin: Structure and function --; 11.8 Gene therapy for Duchenne muscular dystrophy: Future prospects --; References --; 12 Myoblast transplantation in inherited myopathies --; 12.1 Introduction --; 12.2 Myoblast transplantation in animal models of inherited myopathies --; 12.3 Problems associated with myoblast transfer --; Acknowledgements --; References.

متن يادداشت

Molecular and Cell Biology of Muscular Dystrophy gives a series of accounts of various aspects of the remarkable breakthrough which has been achieved in our understanding of the Duchenne/Becker muscular dystrophies and of the consequences and ramifications of this breakthrough.

موضوع مستند نشده

Life sciences.

موضوع مستند نشده

Neurology.

موضوع مستند نشده

Neurosciences.

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

edited by Terence Partridge.

مستند نام اشخاص تاييد نشده

Terence Partridge

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y