عنوان

Nuclear factor kB :

شابک

9401001634

شابک

9401039836

شابک

9789401001632

شابک

9789401039833

شماره

b594199

عنوان اصلي

Nuclear factor kB :

نام عام مواد

[Book]

ساير اطلاعات عنواني

regulation and role in disease

نام نخستين پديدآور

edited by Rudi Beyaert.

محل نشرو پخش و غیره

Dordrecht

نام ناشر، پخش کننده و غيره

Springer Netherlands : Imprint : Springer

تاریخ نشرو بخش و غیره

2003

نام خاص و کميت اثر

(XI, 426 pages)

متن يادداشت

Activators and Target Genes of Rel/NF-?B Transcription Factors --; From Bench to Bedside --; NF-?B Activation by Tumor Necrosis Factor and Interleukin-1 --; NF-?B Activation by CARD Proteins --; Viruses as Intruders in the Rel/NF-?B Signaling Pathway --; The I?B Kinase (IKK) Complex --; The Role of Ubiquitin in NF-?B Signaling --; New Insights into the Regulation of NF-?B --; Roles for Phosphorylation and Acetylation of NF-?B Subunits --; The Structural Biology of NF-?B --; Tools to Interfere with NF-?B Activation --; Regulation of NF-?B by Glucocorticoids --; Genetic Analysis of NF-?B-dependent Signaling Pathways in Mammalian Cells --; Delineation of NF-?B Signaling by Gene Targeting --; The Role of NF-?B in Inflammatory Diseases --; NF-?B in Genetic Disorders --; NF-?B in the Vascular System --; NF-?B in T-lymphocyte Biology --; NF-?B in the Nervous System --; NF-?B in Oncogenesis and as a Target for Cancer Therapy --; Control of Immunity by Rel Proteins in Drosophila.

متن يادداشت

The transcription factor NF-kappaB and the signaling pathways regulating its activity constitute a paradigm of membrane to nucleus communication. NF-kappaB is central to a number of cellular functions including cell proliferation, apoptosis, and cellular differentiation. This transcription factor also plays essential roles in innate and acquired immunity, and its deregulation leads to important human diseases such as inflammation and cancer. Therefore NF-kappaB, together with the signaling pathways leading to its activation, constitute an attractive therapeutic target. This book is the first to review and synthesize our knowledge on this interesting transcription factor. It will be of great interest for those entering or already actively working in the NF-kappaB field, as well as a valuable reference for students, established researchers, or clinicians with wider interests in the fields of molecular cell biology and biomedicine.

موضوع مستند نشده

Immunology.

موضوع مستند نشده

Medicine.

موضوع مستند نشده

Oncology.

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

edited by Rudi Beyaert.

مستند نام اشخاص تاييد نشده

Rudi Beyaert

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y