عنوان

Presenilins and Alzheimer's Disease

شابک

3642721036

شابک

3642721052

شابک

9783642721038

شابک

9783642721052

شماره

b573059

عنوان اصلي

Presenilins and Alzheimer's Disease

نام عام مواد

[Book]

نام نخستين پديدآور

edited by S.G. Younkin, R.E. Tanzi, Y. Christen.

محل نشرو پخش و غیره

Berlin, Heidelberg

نام ناشر، پخش کننده و غيره

Springer Berlin Heidelberg

تاریخ نشرو بخش و غیره

1998

نام خاص و کميت اثر

(XVI, 100 pages 17 illustrations, 5 illustrations in color.)

عنوان فروست

Research and Perspectives in Alzheimer's Disease, Fondation Ipsen.

متن يادداشت

Molecluar genetics of the presenilins in Alzheimer's Disease --; Alzheimer's Disease: A matter of dominance.-Metabolism and function of presenilin 1 --; Alternative endoproteolysis of the presenilins and familial Alzheimer's disease.-The APP and PS1/2 mutations linked to early onset familial Alzheimer's Disease increase the extracellular concentration of Aß1-42(43).-Mechanistic studies of the effect of presenilins 1 and 2 on APP metabolism.-Presenilin 2 --; APP interactions.

متن يادداشت

The discovery in 1995 that defects in the novel presenilin genes harbor defects which cause up to half of all cases of early onset familial Alzheimer's disease cases has rapidly led to the creation of a new and exciting sub-field in Alzheimer's disease research. This has clearly been evidenced by the fact that over 250 papers have now been published regarding the presenilins since their identification in 1995. One of the earliest findings regarding the role of the presenilins in Alzheimer's disease was the discovery that like familial Alzheimer's disease mutations in the amyloid ß protein precursor gene, those in the presenilins lead to dramatically increased production of ß-amyloid in the brains of AD patients. Additionally, the presenilins appear to play roles in programmed cell death (apoptosis) and in CNS development. The provocative chapters in this book written by some of the most highly respected experts in the area of Alzheimer's disease research present some of the latest information concerning the biological function of the presenilins and how defects in these genes cause Alzheimer's disease. The knowledge contained in this volume should help to accelerate ongoing attempts to develop novel treatments for Alzheimer's disease and related disorders.

موضوع مستند نشده

Cytology.

موضوع مستند نشده

Medicine.

موضوع مستند نشده

Neurosciences.

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

edited by S.G. Younkin, R.E. Tanzi, Y. Christen.

مستند نام اشخاص تاييد نشده

R E Tanzi

مستند نام اشخاص تاييد نشده

S G Younkin

مستند نام اشخاص تاييد نشده

Y Christen

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y