عنوان

Voltage-gated ion channels as drug targets

شابک

3527607749

شابک

3527608141

شابک

9783527607747

شابک

9783527608140

شماره

b563557

عنوان اصلي

Voltage-gated ion channels as drug targets

نام عام مواد

[Book]

نام نخستين پديدآور

edited by David J. Triggle [and others].

محل نشرو پخش و غیره

Weinheim

نام ناشر، پخش کننده و غيره

Wiley-VCH

تاریخ نشرو بخش و غیره

©2006.

نام خاص و کميت اثر

(xii, 479 pages) : figure (some color), table

عنوان فروست

Methods and principles in medical chemistry, v. 29.

متن يادداشت

Introduction : on ion channels / Murali Gopalakrishnan, David Rampe, David Triggle, Wei Zheng --; The voltage-gated ion channel superfamily / William A. Catterall --; State-dependent drug interactions with ion channels / Stefan I. McDonough, Bruce P. Bean --; Assay technologies : techniques available for quantifying drug-channel interactions / Derek Leishman, Gareth Waldron --; Overview of voltage-gated calcium channels / Clinton Doering, Gerald Zamponi --; Drugs active at T-type Ca² channels / Thomas M. Connolly, James C. Barrow --; L-type calcium channels / David J. Triggle --; N-type calcium channels --; Molecular, biophysical and functional properties of voltage-gated sodium channels / Douglas S. Krafte, Mark Chapman, Ken McCormack --; Small molecule blockers of voltage-gated sodium channels / Jesús E. González, Andreas P. Termin, Dean M. Wilson --; Potassium channels : overview of molecular, biophysical and pharmacological properties / Murali Gopalakrishnan, Char-Chang Shieh, Jun Chen --; Kv1.3 potassium channel : physiology, pharmacology and therapeutic indications / K. George Chandy, Heike Wulff, Christine Beeton, Peter A. Calabresi, George A. Gutman, Michael Pennington --; Drugs active at kv1.5 potassium channels / Stefan Peukert, Heinz Gögelein --; Medicinal chemistry of Ca²-activated K channel modulators / Sean C. Turner, Char-Chang Shieh --; Drugs active at ATP-sensitive K channels / William A. Carroll --; Compounds that activate KCNQ(2-5) family of potassium ion channels / Grant McNaughton-Smith, Alan D. Wickenden --; Inherited disorders of ion channels / Kate Bracey, Dennis Wray --; Structural and ligand-based models for HERG and their application in medicinal chemistry / Yi Li, Giovanni Cianchetta, Roy J. Vaz --; Ion channel safety issues in drug development / Armando A. Lagrutta, Joseph J. Salata.

متن يادداشت

Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion cha.

موضوع مستند نشده

Ion channels.

موضوع مستند نشده

Ion Channels.

موضوع مستند نشده

Membranes (Biology)

مستند نام اشخاص تاييد نشده

edited by David J. Triggle [and others].

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y