عنوان

Electron microscopy of axon degeneration a valuable tool in experimental neuroanatomy.

شابک

3540034935

شابک

3662304503

شابک

9783540034933

شابک

9783662304501

شماره

b539358

عنوان اصلي

Electron microscopy of axon degeneration a valuable tool in experimental neuroanatomy.

نام عام مواد

[Book]

نام نخستين پديدآور

[By] John F. Alksne [and others] With 20 figures.

نام ناشر، پخش کننده و غيره

Heidelberg, New York Springer

تاریخ نشرو بخش و غیره

1966

نام خاص و کميت اثر

(31 pages)

عنوان فروست

Ergebnisse der Anatomie und Entwicklungsgeschichte, bd. 39, heft 1.

متن يادداشت

Experimental methods for the mapping of nervous pathways are based partlyon the study of retrograde processes in the perikaryon, partlyon the demonstration of degenerative processes along the peripheral part of a transected axon. For this purpose, the Marchi method by which a selective staining of degenerating myelin is obtained has been extensively used. However, when this method is used the non-myelinated terminals of the transected axons are not stained. The introduction, about two decades ago, of silver impregnation as a means of tracing degenerating axons (especially the Glees and Nauta methods) by which also terminal boutons can be demonstrated, led therefore to revolutionary progress in the investigation of interneuronal connections. Notwithstanding, there are weH known difficulties involved in this kind of research. The capriciousness of the silver methods not seldom results in failure of impregnation with loss of valuable experimental animals. But even when well impregnated sections are used, other fundamental difficulties exist. One of the major problems is to prove beyond doubt that the impregnated structures are degenerating boutons and not merely fragments of non-terminal fibres passing the area under examination. Furthermore, only on occasion will silver impregnation permit one to accurately define the specific part of the receiving neuron on which the impregnated fibres end, i. e., whether the bouton makes contact with soma, dendrite or spine.

موضوع مستند نشده

Electron microscopy.

موضوع مستند نشده

Nervous system -- Degeneration.

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

[By] John F. Alksne [and others] With 20 figures.

مستند نام اشخاص تاييد نشده

John F Alksne

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y