عنوان

Aggregation of therapeutic proteins /

شابک

0470411961 (hardback)

شابک

9780470411964 (hardback)

شماره

dltt

عنوان اصلي

Aggregation of therapeutic proteins /

نام عام مواد

[Book]

نام نخستين پديدآور

edited by Wei Wang, Christopher J. Roberts

محل نشرو پخش و غیره

Hoboken, N.J. :

نام ناشر، پخش کننده و غيره

Wiley,

تاریخ نشرو بخش و غیره

c2010

نام خاص و کميت اثر

xxii, 486 p. :

ساير جزييات

ill. (some col.) ;

ابعاد

25 cm

متن يادداشت

Includes bibliographical references and index

متن يادداشت

Chapter 1. Fundamental structures and behaviors of proteins / Jennifer S. Laurence and C. Russell Middaugh -- Chapter 2. Protein aggregation pathways, kinetics, and thermodynamics / Yi Li and Christopher J. Roberts -- Chapter 3. Identification and impact of aggregation prone regions in proteins and therapeutic monoclonal antibodies / Sandeep Kumar, Xiaoling Wang, and Satish K. Singh -- Chapter 4. External factors affecting protein aggregation / Wei Wang, Ning Li, Stan Speaker -- Chapter 5. Experimental detection and characterization of protein aggregates / Vikas K. Sharma and Devendra S. Kalonia -- Chapter 6. Approaches to control protein aggregation during bulk production / Linda O. Narhi, Yijia Jiang, Rohini Deshpande, Sohye Kang, and Joseph Shultz -- Chapter 7. Protein aggregation and particle formation: effects of formulation, interfaces and drug product manufacturing operations / Hanns-Christian Mahler, Stefan Fischer, Theodore W. Randolph, and John F. Carpenter -- Chapter 8. Approaches to managing protein aggregation in product development / Wei Wang and Nicholas W. Warne -- Chapter 9. Case studies involving protein aggregation / Rahul S. Rajan, Tiansheng Li, and Tsutomu Arakawa -- Chapter 10. Aggregation and immunogenicity of therapeutic proteins / Vasco Filipe, Andrea Hawe, Huub Schellekens, and Wim Jiskoot -- Chapter 11. Regulatory perspective on aggregates as a product quality attribute / Wendy C. Weinberg, Linan Ha, Susan L. Kirshner, Daniela I. Verthelyi

بدون عنوان

0

متن يادداشت

"While significant progress has been made in the past decade, the current understanding of protein aggregation and its consequences is still immature. Aggregation of Therapeutic Proteins provides an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. This book also covers an overview on the causes, consequences, characterization, and control of the aggregation of therapeutic proteins. The knowledge in this book will help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this area"--Provided by publisher

موضوع مستند نشده

Aggregation (Chemistry)

موضوع مستند نشده

Protein drugs

موضوع مستند نشده

Cell Aggregation

موضوع مستند نشده

Protein Conformation

موضوع مستند نشده

Protein Folding

موضوع مستند نشده

Recombinant Proteins-- metabolism

موضوع مستند نشده

Recombinant Proteins-- therapeutic use

شماره

ويراست

شماره رده

نشانه اثر

شماره رده

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

Roberts, Christopher John,1972-

مستند نام اشخاص تاييد نشده

Wang, Wei,1957 March 10-

تاريخ عمليات

20110120093422.0

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y